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Z-D-Ala-gPhe-mGly-OEt is a synthetic pentapeptide, a chain of five amino acids, with the sequence Z-D-Ala (benzyl-protected D-alanine), gPhe (gamma-phenylalanine), and mGly (methylglycine), followed by an ethyl ester (OEt) at the C-terminus. This specific sequence and structure are designed to mimic the active components of certain natural peptides, potentially for research or therapeutic purposes. The benzyl group (Z) is a protecting group in peptide chemistry that shields the D-alanine from unwanted reactions until it is removed at a later stage. The gamma-phenylalanine and methylglycine contribute to the peptide's overall conformation and activity. The ethyl ester group at the end of the peptide can influence its solubility and stability, and may also be used to facilitate controlled release or absorption in biological systems. Z-D-Ala-gPhe-mGly-OEt is often used in pharmaceutical research to study peptide interactions and develop new drugs targeting specific receptors or pathways.

95617-41-7

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95617-41-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 95617-41-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,5,6,1 and 7 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 95617-41:
(7*9)+(6*5)+(5*6)+(4*1)+(3*7)+(2*4)+(1*1)=157
157 % 10 = 7
So 95617-41-7 is a valid CAS Registry Number.

95617-41-7Downstream Products

95617-41-7Relevant academic research and scientific papers

Synthesis and Pharmacological Activity of Partially Modified Retro-Inverso Dermorphin Tetrapeptides

Salvadori, Severo,Marastoni, Mauro,Balboni, Gianfranco,Sarto, Gian Pietro,Tomatis, Roberto

, p. 769 - 774 (2007/10/02)

We studied the effect of partial retro-inverso modification of selected peptide bonds of N-terminal tetrapeptide analogues of dermorphin (H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2).Among the 14 compounds synthesized and tested for opioid activity, some tetrapeptides have the C-terminus carrying different amide moieties; retromodifications concern the Phe-Gly bond (Ia-f) and/or the C-terminal carboxamide function (IIIa-d, IIa-d).All pseudotetrapeptide derivatives showed opioid activity in vitro and in vivo.The most potent compounds (II) have a biological potency comparable with that of the original tetrapeptides in the guinea pig ileum preparation and in the mouse tail-flick test after intracerebral or subcutaneous administration.

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