956219-13-9Relevant academic research and scientific papers
Generation of arynes triggered by sulfoxidemetal exchange reaction of ortho-sulfinylaryl triflates
Yoshida, Suguru,Uchida, Keisuke,Hosoya, Takamitsu
, p. 116 - 118 (2014)
Arynes were efficiently generated from readily available ortho-sulfinylaryl triflates by the treatment with phenylmagnesium bromide in tetrahydrofuran at 78 C. Aryne generation was initiated by a rapid sulfoxidemetal exchange reaction, followed by the immediate elimination of the ortho-OTf group. Various arynophiles efficiently reacted with arynes generated by this method within 10min, providing the corresponding adducts in high yields.
Facile preparation of 2-iodophenyl trifluoromethanesulfonates: Superior aryne precursors
Ganta, Ashok,Snowden, Timothy S.
, p. 2227 - 2231 (2008/02/10)
A comparative study of 3-methoxyaryne precursors revealed 2-iodo-3-methoxyphenyl triflate as the most effective in nonpolar solvent. Use of Hoppe's N-isopropyl carbamate allows for the systematic preparation of a variety of 2-iodophenyl triflates via a directed ortho-lithiation-iodination- decarbamation sequence. These steps are possible without isolation of the intermediate iodophenyl carbamates. Georg Thieme Verlag Stuttgart.
