121980-50-5Relevant academic research and scientific papers
The Regioselective Synthesis of Halophenols
Rege, Francis M. G. De,Buchwald, Stephen L.
, p. 4291 - 4296 (1995)
The reactions of borates and borinates with zirconocene complexes of substituted benzynes lead regioselectively to heterodimetallic compounds which were, without isolation, converted to the corresponding halophenols.
Regioselectivity Influences in Platinum-Catalyzed Intramolecular Alkyne O-H and N-H Additions
Costello, Jeff P.,Ferreira, Eric M.
supporting information, p. 9934 - 9939 (2019/12/24)
The steric and electronic drivers of regioselectivity in platinum-catalyzed intramolecular hydroalkoxylation are elucidated. A branch point is found that divides the process between 5-exo and 6-endo selective processes, and enol ethers can be accessed in good yields for both oxygen heterocycles. The main influence arises from an electronic effect, where the alkyne substituent induces a polarization of the alkyne that leads to preferential heteroatom attack at the more electron-deficient carbon. The electronic effects are studied in other contexts, including hydroacyloxylation and hydroamination, and similar trends in directionality are predominant although not uniformly observed.
Double heteroatom functionalization of arenes using benzyne three-component coupling
Garca-Lpez, Jos-Antonio,etin, Meliha,Greaney, Michael F.
supporting information, p. 2156 - 2159 (2015/02/19)
Arynes participate in three-component coupling reactions with N, S, P, and Se functionalities to yield 1,2-heteroatom-difunctionalized arenes. Using 2-iodophenyl arylsulfonates as benzyne precursors, we could effectively add magnesiated S-, Se-, and N-nucleophilic components to the strained triple bond. In the same pot, addition of electrophilic N, S, or P reagents and a copper(I) catalyst trapped the intermediate aryl Grignard to produce a variety of 1,2- difunctionalized arenes.
NOVEL COMPOUNDS
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Paragraph 0208; 0209, (2014/11/11)
The invention provides compounds of formula (I): Said compounds being modulators of Kv3 channels and of use in the prophylaxis or treatment of related disorders.
HYDANTOIN DERIVATIVES USEFUL AS KV3 INHIBITORS
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Page/Page column 26; 27, (2013/06/27)
The invention provides compounds of formula (I): Said compounds being modulators of Kv3 channels and of use in the prophylaxis or treatment of related disorders.
HYDANTOIN DERIVATIVES USEFUL AS KV3 INHIBITORS
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Paragraph 0618-0619, (2013/10/22)
The invention provides compounds of formula (I): Said compounds being inhibitors of Kv3 channels and of use in the prophylaxis or treatment of related disorders.
Hydrogen bonding and alcohol effects in asymmetric hypervalent iodine catalysis: Enantioselective oxidative dearomatization of phenols
Uyanik, Muhammet,Yasui, Takeshi,Ishihara, Kazuaki
supporting information, p. 9215 - 9218 (2013/09/12)
Iodine chooses: A conformationally flexible C2-symmetric organoiodine(III) catalyst for the highly enantioselective catalytic oxidative dearomatization of phenols has been developed. Catalysis is controlled by intramolecular hydrogen-bonding interactions and additional achiral alcohols. Copyright
HYDANTOIN DERIVATIVES USEFUL AS KV3 INHIBITORS
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Page/Page column 82-83, (2012/06/30)
The invention provides compounds of formula (I): Said compounds being inhibitors of Kv3 channels and of use in the prophylaxis or treatment of related disorders.
Facile preparation of 2-iodophenyl trifluoromethanesulfonates: Superior aryne precursors
Ganta, Ashok,Snowden, Timothy S.
, p. 2227 - 2231 (2008/02/10)
A comparative study of 3-methoxyaryne precursors revealed 2-iodo-3-methoxyphenyl triflate as the most effective in nonpolar solvent. Use of Hoppe's N-isopropyl carbamate allows for the systematic preparation of a variety of 2-iodophenyl triflates via a directed ortho-lithiation-iodination- decarbamation sequence. These steps are possible without isolation of the intermediate iodophenyl carbamates. Georg Thieme Verlag Stuttgart.
The metal complex and homochiral diphosphines
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Page 21-22, (2010/02/11)
Novel chiral diphosphines (R) or (S), and their use as optically active ligand for preparing diphosphino-metallic complexes, and the diphosphino-metallic complexes containing said chiral diphosphines (R) or (S), and the use of the diphosphino-metallic com
