95632-46-5

Basic information

• Product Name: SUC-ALA-PRO-PNA
• Synonyms: SUC-ALA-PRO-PNA;Suc-AP-pNA
• CAS NO: 95632-46-5
• Molecular Formula: C₁₈H₂₂N₄O₇
• Molecular Weight: 406.39
• Mol File: 95632-46-5.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: -15°C
• CAS DataBase Reference: SUC-ALA-PRO-PNA(CAS DataBase Reference)
• NIST Chemistry Reference: SUC-ALA-PRO-PNA(95632-46-5)
• EPA Substance Registry System: SUC-ALA-PRO-PNA(95632-46-5)

Safety Data

• Hazardous Substances Data: 95632-46-5(Hazardous Substances Data)

Upstream product

• 108-30-5 succinic acid anhydride 
• 60189-44-8 H-Ala-Pro-pNA 

Relevant articles and documents

Similarities of the substrate cleavage catalyzed by proline specific endopeptidase and dipeptidyl peptidase IV.

16 substrates of the types succinyl-alanyl-alanine-pX-anilide, and succinyl-alanyl-proline-pX anilide having different substituents in para-position of the aryl residue were synthesized and characterized. The influence of electronic as well as hydrophobic substituent constants, sigma and pi, on the hydrolysis of the substrates catalyzed by the enzyme Proline Specific Endopeptidase (PSE) has been investigated. In the Hansch approach, the catalytic constants lg kcat and lg (kcat/KM) of succinyl-alanyl-alanine-pX-anilides hydrolyzed by PSE correlate significantly with electronic substituent constants sigma, whereas no correlation in the case of succinyl-alanyl-proline-pX-anilides. The intercorrelation of the constants of the former substrates with corresponding data from Dipeptidyl Peptidase IV (DP IV) catalyzed hydrolysis of alanyl-alanine-pX-anilides suggest that both enzymes act by similar catalytic mechanism.