956325-23-8

Upstream product

• 5691-19-0 rac-trans-2-aminocyclohexanecarboxylic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 213993-31-8 (1S,2S)-2-amino-cyclohexylmethanol 

Downstream Products

• 959976-85-3 {(1S,2S)-2-[(tert-butoxycarbonyl)amino]cyclohexyl}methyl methanesulfonate 
• 956325-28-3 tert-butyl ((1S,2S)-2-formylcyclohexyl)carbamate 

Relevant academic research and scientific papers

PIPERAZINE DERIVATIVES AS HIV PROTEASE INHIBITORS

The present invention is directed to compounds of Formula I pharmaceutical compositions comprising the same, and their use in the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS.

Novel Compounds

Compounds of Formulae I, or pharmaceutically acceptable salts thereof: wherein X, R1, R2 and R3 are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.