213993-31-8

Upstream product

• 24716-94-7 (1S,2S)-2-aminocyclohexanecarboxylic acid ethyl ester 
• 4336-20-3 dimethyl 1,2-cyclohexanedicarboxylate 
• 5691-19-0 rac-trans-2-aminocyclohexanecarboxylic acid 
• 1655-06-7 (1R,2S)-ethyl 2-hydroxycyclohexanecarboxylate 
• 1379691-07-2 (1S,2S)-2-(N-benzyl-N-((S)-α-methylbenzyl)amino)cyclohexanecarboxylic acid 
• 1379691-05-0 (1R,2S)-ethyl 2-(N-benzyl-N-((S)-α-methylbenzyl)amino)cyclohexanecarboxylate 
• 1617-22-7 cyclohex-1-enecarboxylic acid ethyl ester 
• 1315564-11-4 ethyl 2-(4-methylbenzenesulfonyloxy)cyclohexanecarboxylate 
• 191986-95-5 (1S,2S)-ethyl 2-((S)-1-phenylethylamino)cyclohexanecarboxylate 
• 191986-93-3 (1R,2S)-ethyl 2-((S)-1-phenylethylamino)cyclohexanecarboxylate 
• 1346773-51-0 (1R,2S)-ethyl 2-((S)-1-phenylethylamino)cyclohexanecarboxylate hydrochloride 
• 1346773-51-0 (1S,2S)-ethyl 2-((S)-1-phenylethylamino)cyclohexanecarboxylate hydrochloride 
• 1260890-62-7 (1S,2S)-2-[(S)-1-phenylethylamino]cyclohexylmethanol 
• 53898-03-6 2-(S-1-phenylethylamino)-cyclohex-1-enecarboxylic acid ethyl ester 

Downstream Products

• 956325-23-8 tert-butyl ((1S,2S)-2-(hydroxymethyl)cyclohexyl)carbamate 
• 1379691-06-1 (1S,2S)-2-(benzothiazol-2-ylamino)cyclohexylmethanol 
• 144478-68-2 (2R,3aR,7aS)-1-Benzoyl-octahydro-indole-2-carbonitrile 
• 144478-69-3 (2S,3aR,7aS)-1-Benzoyl-octahydro-indole-2-carbonitrile 
• 144540-73-8 Methanesulfonic acid (1S,2S)-2-(benzoyl-cyanomethyl-amino)-cyclohexylmethyl ester 
• 1158650-42-0 N-Cyanomethyl-N-((1S,2S)-2-hydroxymethyl-cyclohexyl)-benzamide 
• 144478-67-1 ((1S,2S)-2-Hydroxymethyl-cyclohexylamino)-acetonitrile 

Relevant academic research and scientific papers

Isothiourea-mediated asymmetric O- to C-carboxyl transfer of oxazolyl carbonates: Structure-selectivity profiles and mechanistic studies

The structural motif within a series of tetrahydropyrimidine-based isothioureas necessary for generating high asymmetric induction in the asymmetric Steglich rearrangement of oxazolyl carbonates is fully explored, with crossover and dynamic 19F NMR experiments used to develop a mechanistic understanding of this transformation. Copyright

PROCESSES FOR THE SYNTHESIS OF (2S, 3AR, 7AS)-OCTAHYDRO-1H-INDOLE CARBOXYLIC ACID AS AN INTERMEDIATE FOR TRANDOLAPRIL

Processes for the preparation of (2S, 3aR, 7aS) -octahydro-1H-indole-20carboxylic acid hydrochloride starting from (1S, 2S) -2- [ (S) -1- phenylethyl amino] cyclohexyl) methanol are described.

Novel Compounds

Compounds of Formulae I, or pharmaceutically acceptable salts thereof: wherein X, R1, R2 and R3 are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.

Stereoselective synthesis of a trans-octahydroindole derivative, precursor of trandolapril (RU 44 570), an inhibitor of angiotensin converting enzyme

We describe a stereoselective synthesis of the trans-octahydroindole-2-carboxylic acid 2 a key intermediate in the elaboration of Trandolapril (RU 44 570) 1. The optically active starting material used was obtained by an enzymatic hydrolysis.