95633-12-8Relevant academic research and scientific papers
Aza-Reformatsky-type reaction of α-iodomethyl ketone O-alkyl oximes promoted by titanium tetraiodide
Shimizu, Makoto,Toyoda, Tadahiro
, p. 2891 - 2892 (2007/10/03)
An aza-Reformatsky-type reaction of α-iodomethyl ketone O-alkyl oximes was investigated. Simple oximes gave the addition products in poor to moderate yields. The corresponding O-methyl oxime gave an excellent result with 3-phenylpropanal, where the adduct was obtained in 91% yield, while the reaction with cinnamaldehyde gave a poor result. The TiI4 promoted the reaction of α-iodomethyl ketone O-alkyl oximes with aldehyde to give aza-aldol products in good to excellent yields, where the reductive formation of Ti aza-enolate without the use of low valent metal species is noteworthy.
