95637-32-4

Upstream product

• 95-25-0 5-chloro-2-benzoxazolinone 
• 33703-92-3 5-chloro-3-(3-chloropropyl)-2,3-dihydro-1,3-benzoxazol-2-one 
• 92-54-6 4-phenyl-1-piperazine 

Relevant academic research and scientific papers

CsF-Celite catalyzed facile N-alkylation of 2(3H)-benzoxazolones and antimicrobial properties of 2-substituted benzoxazole and 3-substituted-2(3H)- benzoxazolone derivatives

The synthesis and antimicrobial activity studies of a new series of cyclic amine containing benzoxazoles and benzoxazolone-2(3H)-ones derivatives were described. The alkylation of benzoxazolone was carried out using cesium fluoride-Celite. The newly synthesized compounds with the influence of the induction of the cyclic amine moiety in the benzoxazole scaffold have been evaluated with respect to the antibacterial and antifungal activity. The 2-cyclic amine-1,3-benzoxazoles (5a-l), 5-chloro-3-alkyl substituted-1,3- benzoxazol-2(3H)-ones (8a-f), and 3-[3- (cyclic amine)propyl]-1,3-benzoxazol- 2(3H)-ones (9a-f) were synthesized. These derivatives were tested for antibacterial and antifungal activity. Among the compounds tested, 8c and 9f showed moderate to good antibacterial and antifungal activity. Compound 8a showed good antifungal activity. Springer Science+Business Media, LLC 2010.

Synthesis and preliminary evaluation of 2-substituted-1,3-benzoxazole and 3-[(3-substituted)propyl]-1,3-benzoxazol-2(3H)-one derivatives as potent anticancer agents

The synthesis and cytotoxic activity studies of a new series of cyclic amine containing benzoxazole and benzoxazolone derivatives are described. The 2-cyclic amine-1,3-benzoxazoles 5a-k, 5-chloro-3-(3-chloropropyl)- 1,3-benzoxazol-2(3H)-one 8 and 3-[3-(cyclic amino)- propyl]-1,3-benzoxazol-2(3H) -ones 9a-f were synthesized. The newly synthesized compounds with the influence of the presence of cyclic amine moiety in the benzoxazole scaffold have been evaluated with respect to their cytotoxic effect toward four human cancer cell lines. The new compounds were evaluated to see whether substitution at the second and third position of the benzoxazole motif influence their cytotoxic effect toward cancer cells. Springer Science+Business Media, LLC 2011.