956399-85-2Relevant academic research and scientific papers
Antiviral activities of 5-chlorobenzotriazole derivatives
Ibba, Roberta,Corona, Paola,Carta, Antonio,Giunchedi, Paolo,Loddo, Roberta,Sanna, Giuseppina,Delogu, Ilenia,Piras, Sandra
, p. 1247 - 1256 (2018/06/14)
Abstract: In this study, we designed and synthesized a series of new 5-chlorobenzotriazole derivatives. Compounds were tested for cytotoxicity and antiviral activity in cell-based assays against several positive single-stranded RNA viruses: BVDV, YFV, CVB-5, and Sb-1; two negative single-stranded RNA viruses: RSV and VSV; a double-stranded RNA virus (Reo-1); and two DNA viruses: VV and HSV-1. N-[4-(5-Chloro-2H-benzo[d][1,2,3]triazol-2-yl)phenyl]-3,4,5-trimethoxybenzamide turned out to be the most potent compound against?bovine viral diarrhea virus (BVDV). Its activity was shown to be comparable to the activity of the reference drug NM 107 (EC50 3.0 vs. 1.7?μM). It is going to be used as a lead compound for future antiviral drug developments. Graphical abstract: [Figure not available: see fulltext.].
Compounds and amyloid probes thereof for therapeutic and imaging uses
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Page/Page column 30; 33, (2008/06/13)
The present invention provides compounds and amyloid probes thereof that allow for an antemortem method of diagnosing AD and quantitating the extent or progression of amyloid deposits (plaques) by in vivo imaging of amyloid and/or amyloid deposits in the
