956403-50-2Relevant academic research and scientific papers
Design of organocatalysts for asymmetric direct syn-aldol reactions
Xu, Xiao-Ying,Wang, Yan-Zhao,Gong, Liu-Zhu
, p. 4247 - 4249 (2007)
Two new organocatalysts 3a and 3b, derived from L-leucine and (S)-β-amino alcohols that were prepared from L-valine, were designed and afforded the direct syn-aldol reactions of a wide scope of aldehydes with various ketones with an excellent diastereomer
Chiral primary amino amide alcohol organocatalyst for the asymmetric Michael addition of 4-hydroxycoumarin with α,β-unsaturated ketones
Kumagai, Jun,Kohari, Yoshihito,Seki, Chigusa,Uwai, Koji,Okuyama, Yuko,Kwon, Eunsang,Nakano, Hiroto
, p. 1124 - 1134 (2015/04/27)
Chiral primary amino amide organocatalysts were designed and synthesized as new organocatalysts for the enantioselective Michael addition of 4-hydroxycoumarin with α,β-unsaturated ketones to produce chiral warfarin (up to 56% ee with up to 92% yield).
