78603-95-9

Basic information

• Product Name: (S)-(-)-2-AMINO-3-METHYL-1,1-DIPHENYL-1-BUTANOL
• Synonyms: (s)-2-amino-1,1-diphenyl-3-methyl-1-butanol;(S)-2-Amino-1,1-diphenyl-3-methyl-1-butanol, 1,1-Diphenyl-L-valinol;(S)-(-)-2-Amino-3-methyl-1,1-diphenyl-1-butanol;1,1-Diphenyl-L-valinol;(S)-(−)-2-Amino-3-methyl-1,1-diphenyl-1-butanol;(S)-2-Amino-3-methyl-1,1-diphenyl-1-butanol,99%e.e.
• CAS NO: 78603-95-9
• Molecular Formula: C₁₇H₂₁NO
• Molecular Weight: 255.35
• Product Categories: Chiral Reagents
• Mol File: 78603-95-9.mol
• Article Data: 38

Chemical Properties

• Melting Point: 95-99 °C(lit.)
• Boiling Point: 424.7 °C at 760 mmHg
• Flash Point: 210.6 °C
• Appearance: /
• Density: 1.074 g/cm³
• Vapor Pressure: 5.73E-08mmHg at 25°C
• Refractive Index: 1.576
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 11.20±0.50(Predicted)
• CAS DataBase Reference: (S)-(-)-2-AMINO-3-METHYL-1,1-DIPHENYL-1-BUTANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(-)-2-AMINO-3-METHYL-1,1-DIPHENYL-1-BUTANOL(78603-95-9)
• EPA Substance Registry System: (S)-(-)-2-AMINO-3-METHYL-1,1-DIPHENYL-1-BUTANOL(78603-95-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 78603-95-9(Hazardous Substances Data)

Usage

Chemical Properties

White solid

Uses

(S)-(-)-2-Amino-3-methyl-1,1-diphenyl-1-butanol is a useful intermediate for the synthesis of amino alcohols.

InChI:InChI=1/C17H21NO/c1-13(2)16(18)17(19,14-9-5-3-6-10-14)15-11-7-4-8-12-15/h3-13,16,19H,18H2,1-2H3/t16-/m0/s1

Upstream product

• 6306-52-1 L-valine methylester hydrochloride 
• 7146-15-8 D-Valine methyl ester hydrochloride 
• 100-39-0 benzyl bromide 
• 100-58-3 phenylmagnesium bromide 
• 4070-48-8 L-Valine methyl ester 
• 108-86-1 bromobenzene 
• 17609-47-1 L-Valine ethyl ester hydrochloride 
• 744981-08-6 (S)-2-Amino-3-methyl-butyryl chloride 
• 501-53-1 benzyl chloroformate 
• 1149-26-4 (S)-N-(benzyloxycarbonyl)valine 
• 24210-19-3 methyl (2S)-3-methyl-[(benzyloxy)carbonylamino]butanoate 
• 72-18-4 L-valine 
• 100-59-4 phenylmagnesium chloride 
• 57728-40-2 (-)-2-amino-3-methyl-1,1-diphenylbutanol 

Downstream Products

• 184346-45-0 (S)-5,5-Diphenyl-4-isopropyl-1,3-oxazolidin-2-one 
• 76608-88-3 (E)-1-cyclohexyl-4,4-dimethyl-3-hydroxy-2-(1,2,4-triazol-1-yl)-pent-1-ene 
• 1256742-68-3 (S,Z)-2-hydroxy-6-((1-hydroxy-3-methyl-1,1-diphenylbutan-2-ylamino)methylene)cyclohexa-2,4-dienone 
• 147600-16-6 (S)-1-N-(1-hydroxy-1,1-diphenyl-3-methylbut-2-yl)-2-hydroxybenzaldimine 
• 130432-39-2 (S)-1-hydroxy-3-methyl-1,1-diphenylbutan-2-aminium chloride 
• 162213-03-8 2,6-bis<5',5'-diphenyl-4'-(S)-isopropyl oxazolin-2'-yl>pyridine 

Relevant articles and documents

Simple primary β-amino alcohols as organocatalysts for the asymmetric Michael addition of β-keto esters to nitroalkenes

Simple primary β-amino alcohols act as an efficient organocatalysts in the asymmetric Michael addition of β-keto esters with nitroalkenes affording highly pure chiral Michael adducts. Also, both enantiomers of the adducts were obtained, depending on the specific catalyst used and reaction temperature.

The Asymmetric Aza-silyl-Prins Reaction: Synthesis of Enantiopure Piperidines

The design and development of the first asymmetric aza-silyl-Prins reaction is reported, giving rise to valuable and diverse piperidines and pipecolic acid derivatives in both high yields and as single enantiomers. The creation of a novel chiral auxiliary-homoallylic amine for the aza-silyl-Prins reaction is essential to its success.

NeoPHOX - A structurally tunable ligand system for asymmetric catalysis

A synthesis of new NeoPHOX ligands derived from serine or threonine has been developed. The central intermediate is a NeoPHOX derivative bearing a methoxycarbonyl group at the stereogenic center next to the oxazoline N atom. The addition of methylmagnesiu