956427-79-5

Upstream product

• 956427-80-8 tert-butyl (2-(4-nitrobenzamido)-4-(thiophen-2-yl)phenyl)carbamate 
• 122-04-3 4-nitro-benzoyl chloride 
• 457-52-3 4-(2,2,2-trifluoro-acetylamino)-benzoyl chloride 
• 404-26-2 4-(trifluoroacetamido)benzoic acid 
• 150-13-0 4-amino-benzoic acid 
• 335255-43-1 tert-butyl 2-amino-4-(thiophen-2-yl)phenylcarbamate 
• 335254-95-0 tert-butyl (2-nitro-4-(thiophen-2-yl) phenyl)carbamate 
• 875-51-4 4-Bromo-2-nitroaniline 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 956427-82-0 di-tert-butyl 2,2'-{[4-({[2-[(tert-butoxycarbonyl)amino]-5-(2-thienyl)phenyl]amino}carbonyl)phenyl]imino}diacetate 
• 956427-90-0 tert-butyl [2-[(4-aminobenzoyl)amino]-4-(2-thienyl)phenyl][2-(methylamino)-2-oxoethyl]carbamate 
• 956427-91-1 tert-butyl [2-{[4-({3-[acetyl(methyl)amino]propanoyl}amino)benzoyl]amino}-4-(2-thienyl)phenyl]carbamate 
• 956427-56-8 2,2'-{[4-({[2-amino-5-(3-thienyl)phenyl]amino}carbonyl)phenyl]imino}diacetic acid 
• 956427-84-2 2,2'-{[4-({[2-[(tert-butoxycarbonyl)amino]-5-(2-thienyl)phenyl]amino}carbonyl)phenyl]imino}diacetate 

Relevant academic research and scientific papers

HDAC DEGRADER

The disclosure provides compounds of formula (I). The compounds may be used to degrade the Histone Deacetylase (HDAC) family of enzymes, particularly HDAC1, 2 and 3 that exist in corepressor complexes. Accordingly, the compounds may

Selective HDAC inhibitors with potent oral activity against leukemia and colorectal cancer: Design, structure-activity relationship and anti-tumor activity study

Previously, we reported the discovery of a series of N-hydroxycinnamamide-based HDAC inhibitors, among which compound 11y exhibited high HDAC1/3 selectivity. In this current study, structural derivatization of 11y led to a new series of benzamide based HDAC inhibitors. Most of the compounds exhibited high HDACs inhibitory potency. Compound 11a (with 4-methoxybenzoyl as N-substituent in the cap and 4-(aminomethyl) benzoyl as the linker group) exhibited selectivity against HDAC1 to some extent, and showed potent antiproliferative activity against several tumor cell lines. In?vivo studies revealed that compound 11a displayed potent oral antitumor activity in both hematological tumor cell U937 xenograft model and solid tumor cell HCT116 xenograft model with no obvious toxicity. Further modification of benzamide 3, 11a and 19 afforded new thienyl and phenyl compounds (50a, 50b, 63a, 63b and 63c) with dramatic HDAC1 and HDAC2 dual selectivity, and the fluorine containing compound 56, with moderate HDAC3 selectivity.

PHOSPHORUS DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS

The present invention relates to a novel class of phosphorus derivatives. The phosphorus compounds can be used to treat cancer. The phosphorus compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differe

DISUBSTITUTED ANILINE COMPOUNDS

The present invention relates to a novel class of disubstituted aniline compounds. These compounds can inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neo