956485-04-4

Upstream product

• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 956485-03-3 (1R,3R,4R,7S)-7-(tert-butyldimethylsilyloxy)-1-[1-(R)-(4,4'-dimethoxytrityloxy)ethyl]-3-(4-N-benzoyl-cytosin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane 

Downstream Products

• 956485-05-5 (1R,3R,4R,7S)-7-[2-cyanoethoxy(diisopropylamino)phosphinoxy]-1-[1-(R)-(4,4'-dimethoxytrityloxy)ethyl]-3-(4-N-benzoyl-cytosin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane 

Relevant academic research and scientific papers

5'-SUBSTITUTED BICYCLIC NUCLEOSIDES AND OLIGOMERIC COMPOUNDS PREPARED THEREFROM

Provided herein are novel 5'-(S)-CH3 substituted bicyclic nucleosides, oligomeric compounds prepared therefrom and methods of using the oligomeric compounds. More particularly, the furanose ring of each of the novel 5'-(S)-CH3 substi

Configuration of the 5′-methyl group modulates the biophysical and biological properties of locked nucleic acid (LNA) oligonucleotides

As part of a program aimed at exploring the structure- activity relationships of 2′,4′-bridged nucleic acid (BNA) containing antisense oligonucleotides (ASOs), we report the synthesis and biophysical and biological properties of R- and S-5′-Me LNA modifie