956485-03-3Relevant academic research and scientific papers
Configuration of the 5′-methyl group modulates the biophysical and biological properties of locked nucleic acid (LNA) oligonucleotides
Seth, Punit P.,Allerson, Charles R.,Siwkowski, Andrew,Vasquez, Guillermo,Berdeja, Andres,Migawa, Michael T.,Gaus, Hans,Prakash, Thazha P.,Bhat, Balkrishen,Swayze, Eric E.
, p. 8309 - 8318 (2010)
As part of a program aimed at exploring the structure- activity relationships of 2′,4′-bridged nucleic acid (BNA) containing antisense oligonucleotides (ASOs), we report the synthesis and biophysical and biological properties of R- and S-5′-Me LNA modifie
