95656-67-0

Usage

Uses

Used in Pharmaceutical Industry:
1-(4'-amino-3'-chloro-5'-trifluoromethyl-phenyl)-2-cyclobutylamino-ethanol is used as a potential drug candidate for [application reason] due to its unique structural features and potential biological activities. Further research and testing are required to explore its full potential and properties.
(Note: The "application reason" is not provided in the materials, so it is left blank. It could be filled in with a specific reason once the compound's properties and potential uses are better understood through further research.)

Upstream product

• 97760-76-4 4'-amino-3'-chloro-5'-trifluoromethyl-acetophenone 
• 97760-87-7 1-[4-Amino-3-chloro-5-(trifluoromethyl)phenyl]-2-bromoethanone 

Relevant academic research and scientific papers

Synthesis of further amino-halogen-substituted phenyl-aminoethanols

Starting from clenbuterol as a lead structure, new 4-amino-phenyl-aminoethanol analogues have been synthesized by different approaches. In these compounds one or both of the chlorine atoms of clenbuterol are replaced by other residues. This has led to compounds with high intrinsic β2-mimetic and/or β1-blocking activities. 1-(4-Amino-3-chloro-5-trifluoromethyl-phenyl)-2-tert.-butylamino-ethanol hydrochloride (mabuterol) has been selected for clinical development. A detailed description is also given of the syntheses of new intermediate acetophenone derivatives as well as of the resolution of mabuterol into its enantiomers.

BRONCHOSPASMOLYTIC 1-(P-AMINO-PHENYL)-2-AMINO-ETHANOLS-(1) AND SALTS

Racemic and optically active compounds of the formula wherein R1 is hydrogen, fluorine, chlorine, bromine, iodine or cyano, R2 is fluorine, trifluoromethyl, nitro or cyano, and R3 is alkyl of 3 to 5 carbon atoms, hydroxy(alkyl of 3 to 5 carbon atoms), cycloalkyl of 3 to 5 carbon atoms, 1-(3,4-methylenedioxy-phenyl)-2-propyl or 1-(p-hydroxy-phenyl)-2-propyl, and non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as analgesics, uterospasmolytics, bronchospasmolytics and antispastics for the skeletal musculature, and especially as beta 2-receptor mimetics and beta 1-receptor blockers