95658-81-4

Usage

Uses

Used in Pharmaceutical Industry:
3-Hydroxy-5-Methylbenzonitrile is used as an intermediate in the synthesis of pharmaceuticals for its potential role in the development of new drugs and medicinal compounds.
Used in Dye Production:
3-Hydroxy-5-Methylbenzonitrile is used as a key component in the production of dyes, contributing to the creation of a wide range of colorants for various applications.
Used in Agrochemical Industry:
3-Hydroxy-5-Methylbenzonitrile is utilized in the synthesis of agrochemicals, playing a crucial role in the development of effective and environmentally friendly pesticides and other agricultural chemicals.
Used in Industrial Chemical Production:
3-Hydroxy-5-Methylbenzonitrile serves as a versatile building block in the production of various industrial chemicals, thanks to its unique structure and properties that facilitate the creation of a broad spectrum of chemical compounds.

Upstream product

• 26613-67-2 3-acetoxy-5-methyl-benzoic acid 
• 620-22-4 3-Methylbenzonitrile 
• 124289-21-0 3-bromo-5-methylbenzonitrile 
• 585-81-9 3-hydroxy-5-methylbenzoic acid 
• 872286-49-2 3-acetoxy-5-methyl-benzoic acid amide 

Downstream Products

• 473924-00-4 C₁₅H₁₇NO₃ 
• 1205514-48-2 diethyl-thiocarbamic acid O-(3-cyano-5-methylphenyl) ester 
• 1089728-64-2 3-(4-bromo-2-nitrophenoxy)-5-methylbenzonitrile 
• 1006300-37-3 3-(2,6-Dichloro-5-isopropyl-pyrimidin-4-yloxy)-5-methyl-benzonitrile 
• 729613-60-9 3-cyano-5-methylphenyl acetate 
• 770718-85-9 C₁₈H₁₅FN₂O₅ 

Relevant academic research and scientific papers

Sequential Ir/Cu-Mediated Method for the Meta-Selective C-H Radiofluorination of (Hetero)Arenes

This article describes a sequential Ir/Cu-mediated process for the meta-selective C-H radiofluorination of (hetero)arene substrates. In the first step, Ir-catalyzed C(sp2)-H borylation affords (hetero)aryl pinacolboronate (BPin) esters. The intermediate organoboronates are then directly subjected to copper-mediated radiofluorination with [18F]tetrabutylammonium fluoride to afford fluorine-18 labeled (hetero)arenes in high radiochemical yield and radiochemical purity. This entire process is performed on a benchtop without Schlenk or glovebox techniques and circumvents the need to isolate (hetero)aryl boronate esters. The reaction was automated on a TracerLab FXFN module with 1,3-dimethoxybenzene and a meta-tyrosine derivative. The products, [18F]1-fluoro-3,5-dimethoxybenzene and an 18F-labeled meta-tyrosine derivative, were obtained in 37 ± 5% isolated radiochemical yield and >99% radiochemical purity and 25% isolated radiochemical yield and 99% radiochemical purity, and 0.52 Ci/μmol (19.24 GBq/μmol) molar activity (Am), respectively.

Synthesis of Phenols: Organophotoredox/Nickel Dual Catalytic Hydroxylation of Aryl Halides with Water

A highly effective hydroxylation reaction of aryl halides with water under synergistic organophotoredox and nickel catalysis is reported. The OH group of the resulting phenols originates from water, following deprotonation facilitated by an intramolecular base group on the ligand. Significantly, aryl bromides as well as less reactive aryl chlorides served as effective substrates to afford phenols with a wide range of functional groups. Without the need for a strong inorganic base or an expensive noble-metal catalyst, this process can be applied to the efficient preparation of diverse phenols and enables the hydroxylation of multifunctional pharmaceutically relevant aryl halides.

Pyrazole derivatives

This invention relates to pyrazole derivatives of formula (I) or pharmaceutically acceptable salts, solvates or derivatives thereof, and to processes for the preparation thereof, intermediates used in their preparation of, compositions containing them and the uses of such derivatives. The compounds of the present invention bind to the enzyme reverse transcriptase and are modulators, especially inhibitors thereof. As such, the compounds of the present invention are useful in the treatment of a variety of disorders including those in which the inhibition of reverse transcriptase is implicated. Disorders of interest include those caused by Human Immunodificiency Virus (HIV) and genetically related retroviruses, such as Acquired Immune Deficiency Syndrome (AIDS).