956833-47-9Relevant articles and documents
2-O-Carboxymethylpyrogallol derivatives as PTP1B inhibitors with antihyperglycemic activity
Bhattarai, Bharat Raj,Shrestha, Suja,Ham, Seung Wook,Kim, Kwang Rok,Cheon, Hyae Gyeong,Lee, Keun-Hyeung,Cho, Hyeongjin
, p. 5357 - 5360 (2007)
2-O-Carboxymethylpyrogallol derivatives (4-17) were synthesized, with their in vitro inhibitory activities against PTP1B and in vivo antihyperglycemic effects examined. Compound 14, the most potent among the series, showed a Ki value of 1.1 μM