957-56-2

Usage

Chemical Properties

Dark Purple Solid

InChI:InChI=1/C15H9FO2/c16-10-7-5-9(6-8-10)13-14(17)11-3-1-2-4-12(11)15(13)18/h1-8,13H

Upstream product

• 131-11-3 phthalic acid dimethyl ester 
• 620-97-3 1-(4-fluorophenyl)butan-2-one 
• 85-44-9 phthalic anhydride 
• 87-41-2 2-benzofuran-1(3H)-one 
• 459-57-4 4-fluorobenzaldehyde 
• 618-32-6 Benzoyl bromide 
• 459-22-3 4-fluorophenylacetonitrile 
• 606-23-5 1H-indene-1,3(2H)-dione 
• 352-34-1 4-fluoro-1-iodobenzene 
• 36282-29-8 2'-bromo-2-(p-fluorophenyl)-acetophenone 
• 2558-18-1 3-(4-fluoro-benzylidene)-3H-isobenzofuran-1-one 
• 405-50-5 p-Fluorophenylacetic acid 

Downstream Products

• 1647-73-0 2-(4-fluoro-phenyl)-2-nitro-indan-1,3-dione 
• 778-05-2 2-(4-fluoro-phenyl)-2-nitro-propane-1,3-diol 
• 1535-41-7 1-fluoro-4-(nitromethyl)benzene 

Relevant academic research and scientific papers

Palladium-Catalyzed Direct α-Arylation of Indane-1,3-dione to 2-Substituted Indene-1,3-diones

A straightforward and feasible palladium-catalyzed direct α-arylation of indane-1,3-dione to 2-substituted aryl/heteroaryl indene-1,3-diones has been disclosed for the first time. Optimization of reaction conditions identified tBu-XPhos as a preferred ligand for the bis(acetonitrile)dichloropalladium(II) catalyst. A broad spectrum of aryl iodides and aryl triflates containing electron-donating, electron-withdrawing, and sterically hindered substituents gave an excellent yield for the quick access α-arylated 1,3-diones library.

Synthetic method of medical intermediate polycyclic diketone compound

The invention relates to a synthetic method of a polycyclic diketone compound which can be used as a medical intermediate and is as shown in the formula (III). The synthetic method comprises the following step: in an organic solvent and in nitrogen atmosphere, a compound as shown in the formula (I) and a compound as shown in the formula (II) react in the presence of a catalyst, an oxidizing agent, alkali and a promoter, so as to obtain the compound as shown in the formula (III). In the formula (III), R is H, halogen, C1-C6 alkyl group or C1-C6 alkoxy group, and X is halogen. According to the method, a comprehensive reaction system of the catalyst, the oxidizing agent, alkali and the promoter is adopted, and the organic solvent is appropriately selected. Then, the target product with high yield can be obtained. Requirements of organic synthesis, especially industrial production in the field of synthesis of medical intermediates, can be better met. The product has a broad market prospect.

Phenylindenone isomers as divergent modulators of p38α MAP kinase

Two new fluorophenylindenone derivatives were designed as potential p38α MAPK modulators by preserving the key interactions of the vicinal pyridine/fluorophenyl pharmacophore with the enzyme protein. Interestingly, these two fluorophenylindenone isomers showed divergent activities, with compound 6 behaving as an inhibitor and 5 as a putative activator. These results were rationalized by docking studies and molecular dynamics simulations in terms of stabilization of DFG loop, by compound 5 in a conformation more accessible to phosphorylation.

Efficient and convenient synthesis, characterization, and antimicrobial evaluation of some new tetracyclic 1,4-benzothiazines

In the present study, 20 new tetracyclic 1,4-benzothiazines (4a-4 t) were conveniently synthesized in good yields and characterized by different spectral and physical techniques. The in vitro antimicrobial evaluation of the synthesized benzothiazine derivatives was performed by serial dilution against two Gram-positive bacteria [Bacillus subtilis (MTCC 441) and Staphylococcus epidermidis (MTCC 6880)], two Gram-negative bacteria [Escherichia coli (MTCC 1652) and Pseudomonas aeruginosa (MTCC 424)], and two fungal strains [Candida albicans (MTCC 227) and Aspergillus Niger (MTCC 8189)]. The derivatives 4 l and 4 t were found to be more potent than standard drug, i.e., fluconazole, against A. Niger and C. albicans, respectively.

Palladium-catalyzed chemoselective synthesis of indane-1,3-dione derivatives via tert-butyl isocyanide insertion

A simple and efficient strategy for the synthesis of indane-1,3-dione derivatives through a palladium(0)-catalyzed reaction incorporating tert-butyl isocyanide has been developed. In addition, by applying this protocol as the key step, indenopyrazole derivatives can be easily synthesized in high yields in a one-pot procedure. This methodology is tolerant of a wide range of substrates and applicable to library synthesis.