957059-95-9Relevant academic research and scientific papers
Pyridazine compound and application thereof
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Paragraph 0112; 0118-0119, (2022/04/06)
The invention relates to the field of pesticide compounds, and discloses a pyridazine compound and application thereof, and the pyridazine compound has a structure as shown in a formula (I). The compound provided by the invention can generate a very excellent weeding effect at a low dosage, and shows excellent activity on annual gramineous weeds and broadleaf weeds.
In silico structure-guided optimization and molecular simulation studies of 3-phenoxy-4-(3-trifluoromethylphenyl) pyridazines as potent phytoene desaturase inhibitors
Ma, Dejun,Wang, Dawei,Wang, Jing,Xi, Zhen,Xu, Han,Yang, Lijun,Zhang, Di,Zhou, Nuo
, (2021/12/17)
A series of novel 3-phenoxy-4-(3-trifluoromethylphenyl)pyridazines 2–5 were designed, based on the structure of our previous lead compound 1 through the in silico structure-guided optimization approach. The results showed that some of these new compounds showed a good herbicidal activity at the rate of 750 g ai/ha by both pre-and post-emergence applications, especially compound 2a, which displayed a comparable pre-emergence herbicidal activity to diflufenican at 300–750 g ai/ha, and a higher post-emergence herbicidal activity than diflufenican at the rates of 300–750 g ai/ha. Additionally, 2a was safe to wheat by both pre-and post-emergence applications at 300 g ai/ha, showing the compound’s potential for weed control in wheat fields. Our molecular simulation studies revealed the important factors involved in the interaction between 2a and Synechococcus PDS. This work provided a lead compound for weed control in wheat fields.
Synthesis and herbicidal activities of novel 3-N-substituted amino-6-methyl-4-(3-trifluoromethylphenyl)pyridazine derivatives
Xu, Han,Hu, Xu-Hong,Zou, Xiao-Mao,Liu, Bin,Zhu, You-Quan,Wang, Yong,Hu, Fang-Zhong,Yang, Hua-Zheng
experimental part, p. 6567 - 6572 (2010/04/06)
4-(3-Trifluoromethylphenyl)pyridazine is a new series of compounds with bleaching and herbicidal activities. Starting from ethyl 2-(3- trifluoromethylphenyl)acetate, an important intermediate 7 was synthesized in five steps with a moderate total yield of
