41023-25-0

Upstream product

• 331-33-9 ethyl 3-trifluoromethylphenylacetate 

Downstream Products

• 331-33-9 ethyl 3-trifluoromethylphenylacetate 
• 957059-95-9 diethyl 2-acetyl-3-(3-trifluoromethylphenyl)succinate 
• 911046-92-9 (4-trifluoromethyl-phenoxy)-(3-trifluoromethyl-phenyl)-acetic acid ethyl ester 
• 77053-78-2 (1R,2S)-1-(3-Trifluoromethyl-phenyl)-cyclopropane-1,2-dicarboxylic acid 
• 66504-78-7 1-(m-Trifluormethylphenyl)-1,2-cyclopropandicarboximid 
• 86215-49-8 1-(3-trifluoromethylphenyl)-3-azabicyclo[3.1.0]hexane 
• 146138-06-9 2-(3-Trifluoromethyl-phenyl)-3,6-dihydro-2H-thiopyran-2-carboxylic acid ethyl ester 
• 146138-11-6 2-(3-Trifluoromethyl-phenyl)-3,6-dihydro-2H-thiopyran-2-carboxylic acid methylamide 
• 146138-10-5 2-(3-Trifluoromethyl-phenyl)-3,6-dihydro-2H-thiopyran-2-carboxylic acid 
• 77053-68-0 (1R,2S)-1-(3-Trifluoromethyl-phenyl)-cyclopropane-1,2-dicarboxylic acid diethyl ester 

Relevant academic research and scientific papers

Synthesis and herbicidal activities of novel 3-N-substituted amino-6-methyl-4-(3-trifluoromethylphenyl)pyridazine derivatives

4-(3-Trifluoromethylphenyl)pyridazine is a new series of compounds with bleaching and herbicidal activities. Starting from ethyl 2-(3- trifluoromethylphenyl)acetate, an important intermediate 7 was synthesized in five steps with a moderate total yield of

ALPHA-(TRIFLUOROMETHYL-SUBSTITUTED ARYLOXY, ARYLAMINO, ARYLTHIO OR ARYLMETHYL)-TRIFLUOROMETHYL-SUBSTITUTED PHENYLACETIC ACIDS AND DERIVATIVES AS ANTIDIABETIC AGENTS

Compounds having a formula (1) or a pharmaceutically acceptable salt or prodrug thereof, are provided, and are useful for the treatment of metabolic disorders.

A hetero Diels-Alder approach to novel thiopyran analogues of aprikalim, a potassium channel activator

α-Thioketo-ester (6) derived from Bunte salt (5) has been shown to undergo a hetero Diels-Alder reaction with a variety of dienes to form the basis of a concise synthesis of dihydrothiopyran analogues of the potassium channel activator aprikalim.

Electrochemistry of Ethyl α-Bromo-α-fluoro(phenyl)acetate and some Ethyl α-Bromo(trifluoromethylphenyl)acetates and Electrochemical Synthesis of the Corresponding Diastereoisomeric Diethyl Succinates.

Ethyl α-bromoesters (1)-(5) (ABr) were prepared through NBS bromination of (6)-(10) (AH) respectively.Controlled potential electrolysis of (1)-(5), dissolved in dry dimethylformamide (DMF) containing Et4NClO4 (0.1 M) allows the corresponding succinates (1

1-Aryl-3-azabicyclohexanes, a New Series of Nonnarcotic Analgesic Agents

A series of 1-aryl-3-azabicyclohexanes was synthesized by hydride reduction of 1-arylcyclopropanedicarboximides.Hydroxyphenyl analogues 20, 22, and 24 were prepared by EtSNa-DMF ether cleavage of the corresponding methoxyphenyl analogues 2m, 2n, and 23, respectively, with the secondary amines 20 and 22 going through the N-formyl intermediates 19 and 21.The p-ethoxy analogue 26 was obtained by O-ethylation of 19, followed by base hydrolysis of the amide 25.The greatest analgesic potency in mouse writhing and rat paw-pain assays was observed for para-substituted compounds.Bicifadine, 1-(4-methylphenyl)-3-azabicyclohexane (2b), was the most potent member of the series and is presently undergoing clinical trials in man.Analgesic activity of 2b is limited to the (+) enantiomer 2v, which has the 1R,5S absolute configuration as determined by single-crystal X-ray analysis.The N-methyl analogue (27d) of 2b showed significant analgesic potency, whereas the N-allyl (27a), N-(cyclopropylmethyl) (27b), and N-(n-hexyl) (27c) analogues were inactive.Bicifadine (2b) showed a nonnarcotic profile different from analogous azabicycloalkane and 3-phenylpyrrolidine analgesics.