95713-58-9Relevant academic research and scientific papers
Streptopyrazinones A?D, rare metabolites from marine-derived Streptomyces sp. ZZ446
Chen, Mengxuan,Chai, Weiyun,Zhu, Rongyao,Song, Tengfei,Zhang, Zhizhen,Lian, Xiao-Yuan
supporting information, p. 2100 - 2106 (2018/03/26)
Secondary metabolites from marine-associated actinomycetes are important source for the discovery of novel bioactive compounds. In this study, an actinomycete Streptomyces sp. ZZ446 was isolated from coastal soils and different media were used to culture this isolated marine actinomycete. It has been found that this actinomycete in the liquid medium of 2216 E with sea salt produced five new compounds of streptopyrazinones A?D (1–4) and N-acetyl-L-isoleucine-L-leucinamide (5) as well as six known diketopiperazines (6–11) and one alkaloid (12). Structures of the new compounds were determined by extensive NMR analyses, HRESIMS data, electronic circular dichroism (ECD) calculation, chemical degradation, Marfey's method, and X-ray diffraction analysis. This type of streptopyrazinones A?D (1–4) is rarely found in the natural resources. New compounds 1–5 showed activity in inhibiting the growth of Candida albicans and methicillin-resistant Staphylococcus aureus.
C3 and 2D C3 Marfey's Methods for Amino Acid Analysis in Natural Products
Vijayasarathy, Soumini,Prasad, Pritesh,Fremlin, Leith J.,Ratnayake, Ranjala,Salim, Angela A.,Khalil, Zeinab,Capon, Robert J.
supporting information, p. 421 - 427 (2016/03/05)
We validate the improved resolution and sensitivity of the C3 Marfey's method, including an ability to resolve all Ile isomers, against an array of amino acids commonly encountered in natural products and by comparison to an existing Marfey's m
Investigation of the configurational stabilities of chiral isocyanoacetates in multicomponent reactions
Carney, Daniel W.,Truong, Jonathan V.,Sello, Jason K.
, p. 10279 - 10285 (2012/02/14)
Isocyanoacetates are uniquely reactive compounds characterized by an ambivalent isocyano functional group and an enolizable α-carbon. It is widely believed that chiral α-substituted isocyanoacetates are configurationally unstable in some synthetically use
