957205-21-9Relevant articles and documents
Imidazopyridazine hepatitis C virus polymerase inhibitors. Structure-activity relationship studies and the discovery of a novel, traceless prodrug mechanism
Leivers, Martin,Miller, John F.,Chan, Stephanie A.,Lauchli, Ryan,Liehr, Sebastian,Mo, Wenyan,Ton, Tony,Turner, Elizabeth M.,Youngman, Michael,Falls, J. Greg,Long, Susan,Mathis, Amanda,Walker, Jill
supporting information, p. 1964 - 1975 (2014/04/03)
By reducing the basicity of the core heterocycle in a series of HCV NS5B inhibitors, the hERG liability was reduced. The SAR was then systematically explored in order to increase solubility and enable dose escalation while retaining potency. During this e
