957211-53-9

Upstream product

• 957211-52-8 2-(3-nitro-3'-trifluoromethoxybiphenyl-2-ylmethyl)-3-oxo-3-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]propionic acid ethyl ester 

Downstream Products

• 957211-47-1 2-[3-(1,1,2,2-tetrafluoro-ethoxy)-phenyl]-5-(3-trifluoromethoxy-phenyl)-1,2,3,4-tetrahydro-quinoline 
• 957212-61-2 (αS)-3-nitro-α-[3-(1,1,2,2-tetrafluoroethoxy)-phenyl]-3'-(trifluoromethoxy)-[1,1'-biphenyl]-2-propanol 

Relevant academic research and scientific papers

An efficient and scalable synthesis of (2R,αS)-3,4-dihydro-2-[3-(1,1, 2,2-tetrafluoroethoxy)phenyl]-5-[3-(trifluoromethoxy)phenyl]-α- (trifluoromethyl)-1(2H)-quinolineethanol: A potent CETP inhibitor

An efficient and scalable synthesis of the potent CETP inhibitor, (2R,αS)-3,4-dihydro-2-[3-(1,1,2,2-tetrafluoroethoxy)phenyl] -5-[3-(trifluoromethoxy)phenyl]-α-(trifluoromethyl)-1(2H) -quinolineethanol 1, is described. One of the important intermediates,

1,2,3,4-TETRAHYDRO-QUINOLINE DERIVATIVES AS CETP INHIBITORS

The invention is directed to compounds of Formula (I) described herein useful as CETP inhibitors, compositions containing them, and methods of using them.