957228-82-9Relevant academic research and scientific papers
O-Spiro C-aryl glucosides as novel sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors
Xu, Baihua,Lv, Binhua,Feng, Yan,Xu, Ge,Du, Jiyan,Welihinda, Ajith,Sheng, Zelin,Seed, Brian,Chen, Yuanwei
scheme or table, p. 5632 - 5635 (2010/04/05)
Two series of O-spiro C-aryl glucosides were synthesized and tested for inhibition of hSGLT1 and hSGLT2. 6′-O-Spiro C-aryl glucosides exhibited potent in vitro hSGLT2 inhibitory activity but 2′-O-spiro C-aryl glucosides showed no in vitro hSGLT2 inhibitory activity at a screening concentration of 1 μM.
GLUCOSE TRANSPORT INHIBITORS AND METHODS OF USE
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Page/Page column 17, (2008/06/13)
Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT inhibition.
