957230-65-8 Usage
Uses
Used in Pharmaceutical Industry:
Isofagomine D-Tartrate is used as a human acid β-glucosidase inhibitor for the treatment of Gaucher disease. It helps in managing the symptoms and progression of the disease by increasing the activity of the enzyme GlcCerase, which is deficient in Gaucher patients, and promoting its proper trafficking out of the endoplasmic reticulum.
References
1) Kuriyama?et al.?(2008),?In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell culture; Bioorg. Med. Chem.,?16?7330
2) Steet?et al. (2006),?The iminosugar isofagomine increases the activity of N370S mutant acid beta-glucosidase in Gaucher fibroblasts by several mechanisms; Proc. Natl. Acad. Sci. USA,?103?13813
Check Digit Verification of cas no
The CAS Registry Mumber 957230-65-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,5,7,2,3 and 0 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 957230-65:
(8*9)+(7*5)+(6*7)+(5*2)+(4*3)+(3*0)+(2*6)+(1*5)=188
188 % 10 = 8
So 957230-65-8 is a valid CAS Registry Number.
957230-65-8Relevant academic research and scientific papers
NEW METHOD FOR PREPARING ISOFAGOMINE AND ITS DERIVATIVES
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Page/Page column 25; 28, (2009/01/20)
A method for preparing isofagomine, its derivatives, intermediates and salts thereof using novel processes to make isofagomine from D-(-)-arabinose and L-(-)-xylose.
Tartrate sale of isofagomine and methods of use
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Page/Page column 16, (2008/06/13)
A novel tartaric acid salt of Isafagomine (Isofagomine tartrate) that can be used for the treatment of Gaucher disease is provided. The invention also provides a crystalline form of isofagomine tartrate, method for preparing the salt, a pharmaceutical composition containing the salt, and a method of treating Gaucher disease.
