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957471-88-4

(3R)-1-(8-{[(4-tert-butyl-1,3-thiazol-2-yl)amino]carbonyl}-3-{(E)-2-[1-(4-methoxybenzyl)-1H-tetrazol-5-yl]vinyl}-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl)piperidin-3-yl [2-(dimethylamino)ethyl]carbamate is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • (3R)-1-(8-{[(4-tert-butyl-1,3-thiazol-2-yl)amino]carbonyl}-3-{(E)-2-[1-(4-methoxybenzyl)-1H-tetrazol-5-yl]vinyl}-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl)piperidin-3-yl [2-(dimethylamino)ethyl]carbamate

    Cas No: 957471-88-4

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  • Zhonghe Fountain(Tianjin)Biotech Ltd.
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  • (3R)-1-(8-{[(4-tert-butyl-1,3-thiazol-2-yl)amino]carbonyl}-3-{(E)-2-[1-(4-methoxybenzyl)-1H-tetrazol-5-yl]vinyl}-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl)piperidin-3-yl [2-(dimethylamino)ethyl]carbamate

    Cas No: 957471-88-4

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  • Shanghai YaXian Chemical Co., Ltd
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  • 957471-88-4 Structure

  • Basic information

    1. Product Name: (3R)-1-(8-{[(4-tert-butyl-1,3-thiazol-2-yl)amino]carbonyl}-3-{(E)-2-[1-(4-methoxybenzyl)-1H-tetrazol-5-yl]vinyl}-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl)piperidin-3-yl [2-(dimethylamino)ethyl]carbamate
    2. Synonyms:
    3. CAS NO:957471-88-4
    4. Molecular Formula:
    5. Molecular Weight: 755.901
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 957471-88-4.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (3R)-1-(8-{[(4-tert-butyl-1,3-thiazol-2-yl)amino]carbonyl}-3-{(E)-2-[1-(4-methoxybenzyl)-1H-tetrazol-5-yl]vinyl}-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl)piperidin-3-yl [2-(dimethylamino)ethyl]carbamate(CAS DataBase Reference)
    10. NIST Chemistry Reference: (3R)-1-(8-{[(4-tert-butyl-1,3-thiazol-2-yl)amino]carbonyl}-3-{(E)-2-[1-(4-methoxybenzyl)-1H-tetrazol-5-yl]vinyl}-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl)piperidin-3-yl [2-(dimethylamino)ethyl]carbamate(957471-88-4)
    11. EPA Substance Registry System: (3R)-1-(8-{[(4-tert-butyl-1,3-thiazol-2-yl)amino]carbonyl}-3-{(E)-2-[1-(4-methoxybenzyl)-1H-tetrazol-5-yl]vinyl}-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl)piperidin-3-yl [2-(dimethylamino)ethyl]carbamate(957471-88-4)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 957471-88-4(Hazardous Substances Data)

957471-88-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 957471-88-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,5,7,4,7 and 1 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 957471-88:
(8*9)+(7*5)+(6*7)+(5*4)+(4*7)+(3*1)+(2*8)+(1*8)=224
224 % 10 = 4
So 957471-88-4 is a valid CAS Registry Number.

957471-88-4Downstream Products

957471-88-4Relevant articles and documents

MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 7: Highly soluble and in vivo active quaternary ammonium analogue D13-9001, a potential preclinical candidate

Yoshida, Ken-ichi,Nakayama, Kiyoshi,Ohtsuka, Masami,Kuru, Noriko,Yokomizo, Yoshihiro,Sakamoto, Atsunobu,Takemura, Makoto,Hoshino, Kazuki,Kanda, Hiroko,Nitanai, Hironobu,Namba, Kenji,Yoshida, Kumi,Imamura, Yuichiro,Zhang, Jason Z.,Lee, Ving J.,Watkins, William J.

, p. 7087 - 7097 (2007)

A series of 4-oxo-4H-pyrido[1,2-a]pyrimidine derivatives, substituted at the 2-position with piperidines bearing quaternary ammonium salt side chains, were synthesized and evaluated for their ability to potentiate the activity of the fluoroquinolone levofloxacin (LVFX) and the β-lactam aztreonam (AZT) in Pseudomonas aeruginosa. Attachment of the charged entity using an N-ethylcarbamoyloxy linker led to the discovery of the highly soluble compound 22 (D13-9001), which maintained good potency in vitro and displayed excellent activity in vivo in a rat pneumonia model of P. aeruginosa.

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