957545-05-0

Basic information

• Product Name: 3-tritylsulfenyloxypropan-1-amine
• Synonyms: 3-tritylsulfenyloxypropan-1-amine
• CAS NO: 957545-05-0
• Molecular Weight: 349.497
• Mol File: 957545-05-0.mol

Chemical Properties

• CAS DataBase Reference: 3-tritylsulfenyloxypropan-1-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-tritylsulfenyloxypropan-1-amine(957545-05-0)
• EPA Substance Registry System: 3-tritylsulfenyloxypropan-1-amine(957545-05-0)

Safety Data

• Hazardous Substances Data: 957545-05-0(Hazardous Substances Data)

Upstream product

• 957545-33-4 2-(3-tritylsulfenyloxypropyl)isoindoline-1,3-dione 

Downstream Products

• 957545-15-2 methyl 3-[3-(4,4'-dimethoxytrityloxy)propylcarbamoyl]-5-(3-tritylsulfenyloxypropylcarbamoyl)benzoate 

Relevant articles and documents

Synthesis of branched oligonucleotides with three different sequences using an oxidatively removable tritylthio group

(Chemical Equation Presented) We synthesized a three-way branched oligodeoxynucleotide (ODN) 30-mer using a new branch unit with acid-labile DMTr and oxidatively cleavable TrS groups as orthogonal protecting groups. The branched ODN was successfully synthesized using 5-[3,5-bis(trifluoromethyl) phenyl]-l H-tetrazole and (2R,8aS)-(+)-(camphorylsulfonyl)oxaziridine as the activator of phosphoramidite units and the oxidizing reagent, respectively. We also found that the TrS group was orthogonal to the Lev, TBDMS, and Fmoc groups. These results indicate the possibility of the synthesis of more complex four- and five-way branched ODNs by the combined use of DMTr, TrS, Lev, TBDMS, and Fmoc groups.