95764-33-3Relevant academic research and scientific papers
Synthesis and chiral separation of some antitumor agents
Singh, Satendra,Meyer, Karen L.,Magarian, Robert A.
, p. 81 - 94 (2007/10/03)
Four Z-isomers of 1,1-dichloro-2,2,3-triarylcyclopropane (DTACs), designed as potent antitumor agents, were synthesized from their appropriately substituted ethenes, which were prepared from the Grignard reaction followed by the dehydration of their inter
Ellipticine Derivatives with an Affinity to the Estrogen Receptor, an Approach to Develop Intercalating Drugs with a Specific Effect on the Hormone-Dependent Breast Cancer
Delbarre, Alain,Oberlin, Robert,Roques, Bernard P.,Borgna, Jean-Louis,Rochefort, Henri,et al.
, p. 752 - 761 (2007/10/02)
In order to obtain breast tumor directed agents, we have prepared mixed compounds using estradiol or (E)-clomiphene as specific vectors for the breast tissue and a DNA intercalator from the ellipticine series as cytotoxic agent.Among the newly synthesized
