957782-24-0

Upstream product

• 957782-23-9 (S)-2-((2R,4S,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)propan-1-ol 
• 160238-45-9 (2S)-3-(4-methoxybenzyloxy)-2-methyl-1-propanol 
• 209251-62-7 (2R,3S,4S)-1-[(para-methoxybenxyl)oxy]-2,4-dimethyl-3-hexanol 
• 89238-99-3 O-(4-methoxybenzyl)-trichloroacetimidate 
• 212051-35-9 (R)-methyl 3-((4-methoxybenzyl)oxy)-2-methylpropanoate 
• 171019-25-3 acetic acid (2S,3R,4R)-3-(tert-butyldimethylsilanyloxy)-5-hydroxy-2,4-dimethylpentyl ester 
• 663942-91-4 (2S,3R,4R)-3,5-dihydroxy-2,4-dimethylpentyl acetate 

Downstream Products

• 957782-25-1 (2S,3R)-2-((2R,4R,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)-4-methylpentan-3-ol 
• 957782-26-2 (2R,3R,4R,5R)-5-(tert-butyldimethylsilyloxy)-3-(4-methoxybenzyloxy)-2,4,6-trimethylheptan-1-ol 
• 957782-27-3 (2R,3R,4R,5R)-5-(tert-butyldimethylsilyloxy)-3-(4-methoxybenzyloxy)-2,4,6-trimethylheptyl methanesulfonate 
• 957782-29-5 (R)-2-((2R,4R,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)-4-methylpentan-3-one 

Relevant academic research and scientific papers

Towards the total synthesis of the anti-trypanosomal macrolide, Actinoallolides: Construction of a key linear intermediate

Herein, we describe the synthesis of key intermediate (+)-8 as an essential intermediate including full carbon framework for completing the convergent total synthesis of Actinoallolide A (1). (+)-8 was obtained by Negishi and Stille cross coupling from (+)-9, (+)-10 and (-)-11. Stereo-divergent preparation of two similar units, consisting of three consecutive stereocenters, facilitated the synthesis of (+)-10 and (-)-11.

Enantioselective synthesis of the alcohol moiety of dolabriferol

(Chemical Equation Presented) Dolabriferol is a marine polypropionate characterized by an unusual noncontiguous carbon backbone. The two polypropionate subunits are linked by an ester function. The protected alcohol moiety of dolabriferol was synthesized