(R)-2-((2R,4R,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)propanal

Base Information

• Chemical Name: (R)-2-((2R,4R,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)propanal
• CAS No.: 957782-24-0
• Molecular Formula: C₁₅H₂₀O₄
• Molecular Weight: 264.321
• Mol file: 957782-24-0.mol

Synonyms:(R)-2-((2R,4R,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)propanal

Chemical Property of (R)-2-((2R,4R,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)propanal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-((2R,4R,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)propanal

There total 9 articles about (R)-2-((2R,4R,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)propanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(S)-2-((2R,4S,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)propan-1-ol (957782-23-9) → (R)-2-((2R,4R,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)propanal (957782-24-0)

Guidance literature:

With pyridine; Dess-Martin periodane; In dichloromethane; at 20 ℃; for 3h;

DOI:10.1021/jo701524p

Reference yield: 79.0%

C16H22O3 → (R)-2-((2R,4R,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)propanal (957782-24-0)

Guidance literature:

C₁₆H₂₂O₃; With ozone; In methanol; dichloromethane; at -78 ℃; Inert atmosphere;

With dimethylsulfide; In methanol; dichloromethane; at -78 - 20 ℃; for 6h; Inert atmosphere;

DOI:10.1016/j.tetlet.2015.12.022

Reference yield:

C17H24O5 → (R)-2-((2R,4R,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)propanal (957782-24-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 72.0 mg / KOH; MeOH / CH₂Cl₂ / 20 °C

2: 90 percent / Dess-Martin periodinane; pyridine / CH₂Cl₂ / 3 h / 20 °C

With pyridine; methanol; potassium hydroxide; Dess-Martin periodane; In dichloromethane; 2: Dess-Martin oxidation;

DOI:10.1021/jo701524p

upstream raw materials:

(S)-2-((2R,4S,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)propan-1-ol

(2S,3R,4R)-3,5-dihydroxy-2,4-dimethylpentyl acetate

acetic acid (2S,3R,4R)-3-(tert-butyldimethylsilanyloxy)-5-hydroxy-2,4-dimethylpentyl ester

(R)-methyl 3-((4-methoxybenzyl)oxy)-2-methylpropanoate

Downstream raw materials:

(2S,3R)-2-((2R,4R,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)-4-methylpentan-3-ol

(2R,3R,4R,5R)-5-(tert-butyldimethylsilyloxy)-3-(4-methoxybenzyloxy)-2,4,6-trimethylheptan-1-ol

(2R,3R,4R,5R)-5-(tert-butyldimethylsilyloxy)-3-(4-methoxybenzyloxy)-2,4,6-trimethylheptyl methanesulfonate

(R)-2-((2R,4R,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)-4-methylpentan-3-one