95779-63-8

Upstream product

• 22509-74-6 N-ethoxycarbonylphthalimide 
• 88-74-4 2-nitro-aniline 

Downstream Products

• 98413-72-0 3(R)-[1(S)-carboxy-3-cyclohexylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid 
• 94590-58-6 (R)-3-<(S)-1-carboxy-3-phenylpropyl>amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid 
• 98413-69-5 tert-butyl (R)-3-<(S)-carboxy-3-phenylpropyl>amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetate 
• 98413-58-2 2-((R)-5-tert-Butoxycarbonylmethyl-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-ylamino)-4-(1-methyl-cyclohexyl)-butyric acid ethyl ester 
• 98413-70-8 tert-butyl (R)-3-<(S)-1-benzyloxycarbonyl-3-phenylpropyl>amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetate 
• 98413-54-8 2-((R)-5-tert-Butoxycarbonylmethyl-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-ylamino)-4,4-diphenyl-butyric acid ethyl ester 
• 98413-81-1 2-((R)-5-Carboxymethyl-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-ylamino)-4-(1-methyl-cyclohexyl)-butyric acid ethyl ester; hydrochloride 
• 98413-65-1 (R)-3-<(S)-1-ethoxycarbonyl-3-phenylpropyl>amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid 
• 98413-71-9 3(R)-[1(S)-benzyloxycarbonyl-3-phenylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid hydrochloride 
• 98413-85-5 2-((R)-5-Carboxymethyl-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-ylamino)-4,4-diphenyl-butyric acid ethyl ester; hydrochloride 
• 95779-61-6 C₂₁H₂₀N₂O₅S^(2-)*2Na⁽¹⁺⁾ 
• 95779-56-9 (R)-2-((R)-5-Carboxymethyl-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-ylamino)-4-cyclohexyl-butyric acid ethyl ester; hydrochloride 
• 95779-55-8 3(R)-[1(S)-ethoxycarbonyl-3-cyclohexylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid hydrochloride 
• 103584-46-9 (R)-2-[(R)-5-(1-Carboxy-ethyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-ylamino]-4-cyclohexyl-butyric acid ethyl ester; hydrochloride 

Relevant academic research and scientific papers

BENZAZEPINE-, BENZOXAZEPINE- AND BENZOTHIAZEPINE-N-ACETIC ACID DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Compounds with neutral endopeptidase (NEP) inhibitory activity corresponding to the formula I STR1 in which R 1 is a lower alkoxy-lower-alkyl group whose lower alkoxy radical is substituted by a lower alkoxy group, or a phenyl-lower-alkyl or phenyloxy-lower-alkyl group which can optionally be substituted in the phenyl ring by lower alkyl, lower alkoxy or halogen, or a naphthyl-lower-alkyl group, A is CH 2, O or S,R 2 is hydrogen or halogen,R. sup.3 is hydrogen or halogen,R 4 is hydrogen or a group forming a biolabile ester, andR 5 is hydrogen or a group forming a biolabile ester, and the physiologically acceptable acid addition salts thereof.

Condensed seven-membered ring compounds, their production and use

Novel condensed seven-membered ring compounds of the formula: STR1 [wherein R1 and R2 are independently hydrogen, halogen, trifluoromethyl, lower alkyl or lower alkoxy, or both jointly form tri- or tetramethylene; R3 and R5 are independently hydrogen, lower alkyl or aralkyl; R4 is hydrogen or lower alkyl; R6 is a condensed or non-condensed hetero-alicyclic containing at least one atom of N, O and S as a ring-forming atom which may be substituted; A is an alkylene chain; n is 1 or 2] and salts thereof. These compounds exhibit inhibitory activity on angiotensin converting enzyme and so forth, and are of value as an agent for diagnosis, prevention and treatment of circulatory diseases, such as hypertension, cardiopathy and cerebral apoploxy.