7028-57-1

Basic information

• Product Name: 2-Methyl-2H-1,4-benzothiazin-3(4H)-one, 97%
• Synonyms: 2-Methyl-2H-1,4-benzothiazin-3(4H)-one, 97%;2-methyl-4H-1,4-benzothiazin-3-one
• CAS NO: 7028-57-1
• Molecular Formula: C₉H₉NOS
• Molecular Weight: 179.23886
• Mol File: 7028-57-1.mol
• Article Data: 18

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Methyl-2H-1,4-benzothiazin-3(4H)-one, 97%(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methyl-2H-1,4-benzothiazin-3(4H)-one, 97%(7028-57-1)
• EPA Substance Registry System: 2-Methyl-2H-1,4-benzothiazin-3(4H)-one, 97%(7028-57-1)

Safety Data

• Hazardous Substances Data: 7028-57-1(Hazardous Substances Data)

Upstream product

• 17147-80-7 2-(1-hydroxyethyl)-1,3-benzothiazole 
• 137-07-5 2-amino-benzenethiol 
• 53907-46-3 methyl 2-mercaptopropionate 
• 615-43-0 2-iodophenylamine 
• 95779-63-8 (R)-3-(2-nitrophenyl)thio-2-phthalimidopropionic acid 
• 100236-26-8 (2R)-3-(2-Aminophenylthio)-2-phthalimidopropionsaeure 
• 95779-64-9 (R)-3-phthalimido-2,3-dihydro-1,5(5H)-benzothiazepin-4-one 
• 94590-63-3 (3R)-3-Amino-2,3-dihydro-1,5-benzothiazepin-4(5H)-on 
• 17639-93-9 2-chloro-propionic acid methyl ester 
• 1155-00-6 bis(2-nitrophenyl)disulfide 
• 598-72-1 2-Bromopropionic acid 
• 110704-27-3 2-(1-chloroethyl)benzothiazole 
• 598-78-7 (R,S)-2-chloropropionic acid 
• 27816-36-0 2-Chloropropionamide 

Downstream Products

• 1247021-59-5 2-methyl-4-[2-(trifluoromethyl)benzyl]-2H-1,4-benzothiazin-3(4H)-one 
• 87012-00-8 4-benzoyl-2-methyl-2,3-dihydro-1,4-benzothiazine 
• 87012-09-7 N-benzoyl-N-<2-(methylthio)phenyl>propen-1-ylamine 
• 93301-29-2 4-acetyl-2-benzyl-2-methyl-2,3-dihydro-4H-1,4-benzothiazine 1-oxide 
• 93301-25-8 4-acetyl-2-benzyl-2-methyl-2,3-dihydro-4H-1,4-benzothiazine 
• 93301-21-4 2-benzyl-2-methyl-2,3-dihydro-4H-1,4-benzothiazine 
• 93301-19-0 2,2-dimethyl-2,3-dihydro-4H-1,4-benzothiazine 
• 139605-59-7 5-methyl-[1,2,4]-triazino-6-oxo[3,4-c]-3(1H)-[1,4]benzothiazine 
• 58960-00-2 2-Methyl-2,3-dihydro-4H-1,4-benzothiazine 
• 90921-53-2 2,2-dimethyl-3-oxo-2,3-dihydro-4H-1,4-benzothiazine 
• 97678-16-5 erythro-3,4-dihydro-2(α-hydroxybenzyl)-4H-2-methyl-3-oxo-2H-1,4-benzothiazine 
• 97678-16-5 threo-3,4-dihydro-2(α-hydroxybenzyl)-4H-2-methyl-3-oxo-2H-1,4-benzothiazine 
• 93301-18-9 2-benzyl-2-methyl-3-oxo-2,3-dihydro-4H-1,4-benzothiazine 

Relevant articles and documents

Efficient synthesis of benzene-fused 6/7-membered amides: Via Xphos Pd G2 catalyzed intramolecular C-N bond formation

An efficient approach for benzene-fused 6/7-membered amides via intramolecular amidation of aryl chlorides catalyzed by a Buchwald-Hartwig second generation Pd catalyst (Xphos Pd G2) has been successfully developed. This catalyst system allows the primary amides which have only modest nucleophilicity to be coupled successfully even with electron rich aryl chlorides in short reaction time. The intramolecular amidation reaction also has good chemoselectivity and excellent functional group compatibility.

Facile synthesis of 1,4-benzothiazin-3-ones from Cu-catalyzed coupling of 2-iodoanilines and 2-mercaptoacetate

A novel synthesis of 1,4-benzothiazin-3-ones was developed from Cu-catalyzed coupling of readily available substituted 2-iodoanilines with 2-mercaptoacetate. The new method offers clear advantages over existing approaches for its one-step simple operation, wider reaction scope, and moderate to excellent isolated yields.

EP2/4 AGONISTS

EP2/4 compounds having improved dual pharmacological activity are described. The uniqueness of using EP2/4 dual agonists resides in their ability to modify both uveoscleral outflow via the ciliary muscle and conventional outflow via trabecular meshwork and Schlemm's canal all in the same treatment paradigm. The compounds can be employed for the treatment of glaucoma and ocular hypertension. Formula (I).