958-45-2

Upstream product

• 3306-62-5 2-AMINOBENZENESULFONAMIDE 
• 100-51-6 benzyl alcohol 
• 100-44-7 benzyl chloride 
• 100-39-0 benzyl bromide 

Downstream Products

• 964-08-9 4-Benzyl-3,4-dihydro-2H-1,2,4-benzothiadiazin-3-on-1,1-dioxid 
• 3306-78-3 3-phenyl-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide 
• 18818-44-5 3‐phenyl‐2H‐benzo[e][1,2,4]thiadiazine 1,1‐dioxide 

Relevant academic research and scientific papers

Sulfate Radical Anion (SO4?-) Mediated C(sp3)-H Nitrogenation/Oxygenation in N-Aryl Benzylic Amines Expanded the Scope for the Synthesis of Benzamidine/Oxazine Heterocycles

A transition-metal-free, K2S2O8-mediated intramolecular oxidative nitrogenation/oxygenation of C(sp3)-H in N-aryl benzylic amines followed by oxidation at the benzylic center has been developed for the synthesis of benzamidine/benzoxazine heterocycles, providing an expedient access to quinazolin-4(3H)-ones, N-aryl-2-arylbenzimidazoles, and 4H-3,1-benzoxazin-4-ones. A considerable amount of work dealing with the mechanistic study to understand the crucial intramolecular cyclization step largely favors an iminium ion as the key intermediate.

N-benzylation/benzylic C-H amidation cascade by the (ζ3- Benzyl)palladium system in aqueous media: An effective pathway for the direct construction of 3-phenyl-3,4-dihydro-(2H)-1,2,4-benzothiadiazine 1,1-dioxides

We demonstrate a unique strategy for a benzylation/benzylic C-H amidation cascade reaction by the (ζ3-benzyl)palladium system derived from a palladium catalyst and benzyl alcohol. This tandem process is devised as a new synthetic route for 3-phenyl-3,4-dihydro-(2H)-1,2,4-benzothiadiazine-1,1- dioxide. Water plays an important role for the smooth generation of the (ζ3-benzyl)palladium species, and a bis-benzylated Pd(II) intermediate would be formed in our catalytic system. Atom economical processes such as benzylic C-H activation, cascade reactions and chemoselective reactions in aqueous media have been developed.