95800-92-3Relevant academic research and scientific papers
Coupling of thiols and aromatic halides promoted by diboron derived super electron donors
Franco, Mario,Vargas, Emily L.,Tortosa, Mariola,Cid
supporting information, p. 11653 - 11656 (2021/11/12)
We have proven that pyridine-boryl complexes can be used as superelectron donors to promote the coupling of thiols and aromatic halides through a SRN1 mechanism. The reaction is efficient for a broad substrate scope, tolerating heterocycles including pyridines, enolizable or reducible functional groups. The method has been applied to intermediates in drug synthesis as well as interesting functionalized polythioethers through a controlled and consecutive intramolecular electron transfer process.
Ni nanoparticles on RGO as reusable heterogeneous catalyst: Effect of Ni particle size and intermediate composite structures in C-S cross-coupling reaction
Sengupta, Debasish,Bhowmik, Koushik,De, Goutam,Basu, Basudeb
, p. 1796 - 1806 (2017/09/27)
The present work demonstrates the C-S cross-coupling reaction between aryl halides and thiols using nickel nanoparticles (Ni NPs) supported on reduced graphene oxide (Ni/RGO) as a heterogeneous catalyst. It is observed that the uniformly dispersed Ni NPs supported on RGO could exhibit excellent catalytic activity in C-S cross-coupling reactions and the catalytic application is generalized with diverse coupling partners. Although the electron-rich planar RGO surface helps in stabilizing the agglomeration-free Ni NPs, the catalytic process is found to occur involving Ni(II) species and the recovered catalyst containing both Ni(0)/Ni(II) species is equally efficient in recycle runs. A correlation of loading of Ni species, size of NPs and the intermediate Ni-related heterostructures formed during the catalytic process has been established for the first time, and found to be best in the C-S cross-coupling reaction for Ni(0) and Ni(II) NPs of the average sizes 11-12 nm and 4 nm, respectively.
Disulfides as efficient thiolating reagents enabling selective bis-sulfenylation of aryl dihalides under mild copper-catalyzed conditions
Liu, Yunyun,Wang, Hang,Zhang, Jida,Wan, Jie-Ping,Wen, Chengping
, p. 19472 - 19475 (2014/05/20)
Selective bis-sulfenylation reactions of aryl dihalides have been achieved by copper-catalyzed C-S coupling reactions under mild conditions of refluxing EtOH (80 °C). Employment of disulfides as thiolating reagents enables the production of various bis(phenylthio)benzenes with excellent selectivity, and no products from mono C-S coupling are isolated. the Partner Organisations 2014.
INNOVATIVE APPROACH TO THE SYNTHESIS OF SULPHIDES AND THEIR CORRESPONDING SULPHONES
Abd-El-Aziz, Alaa S.,Epp, Karen M.,Lei, Yun,Kotowich, Steven
, p. 1252 - 1286 (2007/10/02)
A general and efficient synthetic approach to aryl-aryl bis-sulphides with aliphatic or aromatic bridges via the nucleophilic aromatic substitution (SNAr) of cyclopentadienyliron arene complexes with a number of dithiols followed by photolytic demetallation is presented in this work.The oxidation of the bis(cyclopentadienyliron) arene complexes containing bis-sulphide linkages with 3-chlorobenzoic acid gave their corresponding sulphones in very good yield (70-95percent).Mixed ether/sulphide and ether/sulphone complexes were also prepared following the same synthetic strategy.Reactions of sulphide and sulphone diiron complexes with terminal chloro groups with a number of oxygen, sulphur and carbon nucleophiles allowed for the functionalization of these complexes.The use of photolytic demetallation as a means of liberating the modified arene ligands proved to be very successful.The mild conditions, high yields and low cost of the starting iron complexes make this method one of the most general and practical routes to sulphide and sulphone compounds.
