95811-57-7Relevant articles and documents
Employing Arynes for the Generation of Aryl Anion Equivalents and Subsequent Reaction with Aldehydes
Gaykar, Rahul N.,Bhunia, Anup,Biju, Akkattu T.
, p. 11333 - 11340 (2018/07/21)
Arynes are highly reactive intermediates, which are utilized for the electrophilic arylation of various X-H bonds (X = O, N, S etc.). Herein, a new synthetic strategy is demonstrated, where arynes are converted into aryl anion equivalents by treatment with phosphines and a base. The addition of phosphines to arynes form the phosphonium salts, which in the presence of a carbonate base generates the aryl anion equivalent. Subsequent addition of the aryl anions with aldehydes afforded the secondary alcohols.
Enantioselective Addition of Aryl Groups to Aromatic Aldehydes Using Chiral Aryltitanium Binaphthol Derivatives
Seebach, Dieter,Beck, Albert K.,Roggo, Silvio,Wonnacott, Anne
, p. 3673 - 3682 (2007/10/02)
Chiral, non-racemic organotitanium reagents are generated in situ from binaphthol, chlorotriisopropoxytitanium and aryl Grignard reagents in tetrahydrofuran (THF).These reagents transfer aryl groups to aromatic aldehydes with high enantioselectivity .By this method, enantiomerically pure benzhydrols are available (3-13, Table 1).In the cases, in which the absolute configuration of the products is known, the reaction occurs with relative topicity lk.
