958233-17-5Relevant articles and documents
Radioactive molecular probe taking TSPO as target point as well as preparation method and application thereof
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, (2020/05/30)
The invention discloses a small molecular organic compound with a specific targeting TSPO (Transfer Protein). The structure of the small molecular organic compound comprises a benzene ring, pyrazolo imidazole and a diethyl acetamide structure. The P-tolue
TSPO ligands for cancer imaging and treatment
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, (2016/10/24)
Embodiments of the present invention relates to compounds of the following formula: as well as compositions, methods of imaging and methods of treating subjects comprising the use of the compound, wherein the variables are defined herein.
Microwave-assisted organic synthesis of a high-affinity pyrazolo-pyrimidinyl TSPO ligand
Tang, Dewei,Buck, Jason R.,Hight, Matthew R.,Manning, H. Charles
supporting information; experimental part, p. 4595 - 4598 (2010/09/18)
We herein report a dramatically improved total synthesis of the high-affinity translocator protein (TSPO) ligand DPA-714, featuring microwave-assisted organic synthesis (MAOS). Compared with previously described approaches, our novel MAOS method dramatica
Synthesis and biological evaluation of substituted [18F] imidazo[1,2-a]pyridines and [18F]pyrazolo[1,5-a]pyrimidines for the study of the peripheral benzodiazepine receptor using positron emission tomography
Fookes, Christopher J. R.,Pham, Tien Q.,Mattner, Filomena,Greguric, Ivan,Loc'h, Christian,Liu, Xiang,Berghofer, Paula,Shepherd, Rachael,Gregoire, Marie-Claude,Katsifis, Andrew
experimental part, p. 3700 - 3712 (2009/04/11)
The fluoroethoxy and fluoropropoxy substituted 2-(6-chloro-2-phenyl) imidazo[1,2-a]pyridin-3-yl)-N,N-diethylacetamides 8 (PBR102) and 12 (PBR111) and 2-phenyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)-N,N-diethylacetamides 15 (PBR099) and 18 (PBR146) wer
Radiosynthesis of [18F]DPA-714, a selective radioligand for imaging the translocator protein (18 kDa) with PET
Damont, Annelaure,Hinnen, Francoise,Kuhnast, Bertrand,Schoellhorn-Peyronneau, Marie-Anne,James, Michelle,Luus, Christopher,Tavitian, Bertrand,Kassiou, Michael,Dolle, Frederic
, p. 286 - 292 (2008/12/22)
Recently, a novel series of 2-phenylpyrazolo[1,5-α] pyrimidineacetamides has been reported as selective ligands of the translocator protein (18 kDa). Within this series, DPA-714 (N,N-diethyl-2-(2-(4-(2- fluoroethoxy)phenyl)-5,7-dimethylpyrazolo[1,5-α]pyri
2-ARYLPYRAZOLO[L,5-α]PYRIMIDIN-3-YL ACETAMIDE DERIVATIVES AS LIGANDS FOR TRANSLOCATOR PROTEIN (18 KDA)
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, (2008/06/13)
The invention provides compounds of formula (I) radiolabelled with 18F, 123I, 76Br, 124I or75Br and salts thereof, and a method of imaging translocator protein (18kDa) (TSPO) in a subject comprising a