958261-72-8

Upstream product

• 62322-75-2 1-(4-methylphenyl)-3-(2-nitrophenyl)prop-2-en-1-one 
• 1777-53-3 1-(p-tolyl)-2-(triphenylphosphoranylidene)ethanone 
• 552-89-6 2-nitro-benzaldehyde 
• 122-00-9 para-methylacetophenone 

Downstream Products

• 1455213-50-9 (2’R,3’S,4’S)-1-acetyl-2’-benzoyl-4’-(2-oxo-1-(4-methylphenylethyl))-2-oxo-1’-tosylspiro[indoline-3,3’-tetrahydroquinoline] 
• 130820-62-1 2-p-tolyl-1,2,3,4-tetrahydro-4-quinolone 
• 1016275-45-8 (S)-2-(4’-methylphenyl)-1,2,3,4-tetrahydroquinoline 
• 1454837-43-4 (4aR,5R,10bS)-5-phenyl-2-(p-tolyl)-4a,5,6,10b-tetrahydro-4H-pyrano[3,4-c]quinolin-4-one 
• 1432624-92-4 2-((2R,3S,4S)-2-(2-bromophenyl)-3-nitro-1,2,3,4-tetrahydroquinolin-4-yl)-1-phenylethanone 
• 1432624-71-9 2-((2R,3S,4R)-2-(2-bromophenyl)-3-nitro-1,2,3,4-tetrahydroquinolin-4-yl)-1-phenylethanone 

Relevant academic research and scientific papers

Diastereoselective Synthesis of Tetracyclic Tetrahydroquinoline Derivative Enabled by Multicomponent Reaction of Isocyanide, Allenoate, and 2-Aminochalcone

We report here a multicomponent protocol to assemble several polycyclic dihydropyran-fused tetrahydroquinoline structures with excellent diastereoselectivity. This procedure employs simple feedstocks to accomplish a series of diverse structures, which is

Visible-Light Induction/Br?nsted Acid Catalysis in Relay for the Enantioselective Synthesis of Tetrahydroquinolines

An efficient method merging Br?nsted acid catalysis with visible-light induction for the highly enantioselective synthesis of tetrahydroquinolines has been developed. This mild process directly transforms 2-aminoenones into 2-substituted tetrahydroquinolines with excellent enantioselectivities through a relay visible-light-induced cyclization/chiral phosphoric acid-catalyzed transfer hydrogenation reaction.

Asymmetric synthesis of CF3-containing tetrahydroquinoline: Via a thiourea-catalyzed cascade reaction

An organocatalytic asymmetric method for the synthesis of 2-CF3 tetrahydroquinoline has been achieved. The cascade reaction of 2-aminochalcones with β-CF3 nitroalkenes afforded the products bearing three contiguous stereogenic centers in good yields with excellent diastereoselectivities and enantioselectivities.

Organocatalyzed aerobic oxidative Robinson-type annulation of 2-isocyanochalcones: expedient synthesis of phenanthridines

A DBU-catalyzed aerobic oxidative Robinson annulation of 2-isocyanochalcones with active methylene ketones was developed for the expedient synthesis of phenanthridines in high to excellent yields. This unprecedented multistep domino reaction represents a

One pot synthesis of pyrrolo[3,4-c]quinolinone/pyrrolo[3,4-c]quinoline derivatives from 2-aminoarylacrylates/2-aminochalcones and tosylmethyl isocyanide (TosMIC)

An efficient and practical synthetic approach to access to 2H-pyrrolo[3,4-c]quinolin-4(5H)-one/2H-pyrrolo[3,4-c]quinoline derivatives by the reaction of 2-aminoarylacrylates/2-aminochalcones and tosylmethyl isocyanide (TosMIC) via a one pot van Leusen rea

Cinchona-based squaramide-catalysed cascade aza-Michael-Michael addition: Enantioselective construction of functionalized spirooxindole tetrahydroquinolines

An efficient enantioselective cascade aza-Michael-Michael addition reaction catalysed by a chiral bifunctional tertiary amine-squaramide catalyst has been developed. This cascade reaction proceeded well under mild conditions, furnishing highly functionalized spirooxindole tetrahydroquinolines with three contiguous stereocenters in excellent yields with excellent diastereoselectivities (>25:1 dr) and high enantioselectivities (up to 94% ee). The Royal Society of Chemistry 2013.