95832-60-3

Usage

Uses

Used in Pharmaceutical Industry:
(Cyclopentyloxy)acetic acid is used as a key intermediate in the preparation and study of structure-activity relationship of dimethyl(alkyloxy)[(methylsulfonyl)phenyl]furanones. These compounds are potential COX-2 inhibitors, which are important in the development of anti-inflammatory and analgesic drugs. The cyclopentyloxy group in (cyclopentyloxy)acetic acid plays a crucial role in modulating the biological activity and selectivity of the resulting furanone derivatives.

InChI:InChI=1/C7H12O3/c8-7(9)5-10-6-3-1-2-4-6/h6H,1-5H2,(H,8,9)

Upstream product

• 5736-19-6 sodium cyclopentanolate 
• 79-11-8 chloroacetic acid 
• 96-41-3 Cyclopentanol 
• 3926-62-3 sodium monochloroacetic acid 
• 836656-85-0 ethyl cyclopentyloxyacetate 
• 79-08-3 bromoacetic acid 

Downstream Products

• 246869-09-0 cyclopentyloxy-acetic acid 2-(4-methanesulfonyl-phenyl)-1,1-dimethyl-2-oxo-ethyl ester 
• 855929-18-9 2-Cyclopentyloxy-acetamid 
• 1239311-11-5 trans-{4-[4-(5-cyclopentyloxymethyl[1.3.4]thiadiazol-2-ylcarbamoyl)-phenyl]cyclohexyl}acetic acid 
• 1239311-06-8 cis-4-[4-(5-cyclopentyloxymethyl[1,3,4]thiadiazol-2-ylcarbamoyl)phenoxy]cyclohexanecarboxylic acid 
• 1239311-08-0 methyl cis-4-[4-(5-cyclopentyloxymethyl[1.3.4]thiadiazol-2-ylcarbamoyl)phenoxy]cyclohexanecarboxylate 
• 933732-12-8 2-(cyclopentyloxy)ethanamine 

Relevant academic research and scientific papers

Electrochemical methoxymethylation of alcohols-a new, green and safe approach for the preparation of MOM ethers and other acetals

A new, green, safe, cost-effective and highly efficient electrochemical approach for the methoxymethylation of alcohols and phenols was successfully developed. The methodology was also applied to the synthesis of substituted acetals.

THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHOD OF USE

Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1 comprising administering to a subject in need thereof a compound described here.

Potassium Channel Modulators

Disclosed herein are KCNQ potassium channels modulators of formula (I) wherein R1, R2, R3, R4, and R5 are as defined in the specification. Compositions comprising such compounds; and methods for treating conditions and disorders using such compounds and compositions are also described.

SAR in the alkoxy lactone series: The discovery of DFP, a potent and orally active COX-2 inhibitor

Extensive SAR has been established in the alkoxy lactone series and this has lead to the discovery of DFP (5,5-dimethyl-3-(2-propoxy)-4- methanesulfonylphenyl)-2(5H)-furanone), a potent COX-2 inhibitor exhibiting in vivo efficacy in all models studied.