95833-14-0

Basic information

• Product Name: 2-Quinolinol, 7-amino-
• CAS NO: 95833-14-0
• Molecular Formula: C9H8N2O
• Mol File: 95833-14-0.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 2-Quinolinol, 7-amino-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Quinolinol, 7-amino-(95833-14-0)
• EPA Substance Registry System: 2-Quinolinol, 7-amino-(95833-14-0)

Safety Data

• Hazardous Substances Data: 95833-14-0(Hazardous Substances Data)

Upstream product

• 75755-37-2 7-nitroquinoline-2(1H)-one 
• 14753-17-4 7-Nitro-chinolin-1-oxyd 
• 613-51-4 7-nitroquinoline 
• 30450-62-5 7-nitro-1,2,3,4-tetrahydro-quinoline 
• 635-46-1 1,2,3,4-tetrahydroisoquinoline 
• 1116135-32-0 7-amino-3-chloro-3,4-dihydroquinolin-2(1H)-one 

Relevant articles and documents

Discovery of Benzopyridone-Based Transient Receptor Potential Vanilloid 1 Agonists and Antagonists and the Structural Elucidation of Their Activity Shift

Among a series of benzopyridone-based scaffolds investigated as human transient receptor potential vanilloid 1 (TRPV1) ligands, two isomeric benzopyridone scaffolds demonstrated a consistent and distinctive functional profile in which 2-oxo-1,2-dihydroquinolin-5-yl analogues (e.g., 2) displayed high affinity and potent antagonism, whereas 1-oxo-1,2-dihydroisoquinolin-5-yl analogues (e.g., 3) showed full agonism with high potency. Our computational models provide insight into the agonist-antagonist boundary of the analogues suggesting that the Arg557 residue in the S4-S5 linker might be important for sensing the agonist binding and transmitting signals. These results provide structural insights into the TRPV1 and the protein-ligand interactions at a molecular level.

CONDENSED HETEROCYCLIC COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY

The present disclosure provides compounds having affinity for the 5-HT6 receptor which are of the formula (I) wherein R1, A, B, D, E, G, Q, Ar, n, m, and p are as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

4'-AMINO CYCLIC COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY

The present disclosure provides compounds having affinity for the 5-HT6 receptor which are of the formula (I): formula (I) wherein Cy is selected from formula (Il) and wherein R1, R2, R3, Q, G, Ar, m, n and p are as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.