95835-92-0Relevant academic research and scientific papers
Isolation and Structure Elucidation of the By-Product Formed in the Aminomethylation of α-Methylstyrene
Sohar, Pal,Lazar, Janos,Bernath, Gabor
, p. 551 - 559 (2007/10/02)
Aminomethylation of α-Methylstyrene (1) leads to 1,2,3,6-tetrahydro-4-phenylpyridine (3) as main product, together with a significant amount of a previously unknown by-product.The N-methyl, O-acetyl-N-methyl, N,O-diacetyl, N-(4-nitrobenzoyl), and (via N -> O acyl-migration) O-(4-nitrobenzoyl) derivatives of the by-product were synthesized.By aromatization of the heteroring, 4-phenyl-3-pyridinemethanol (8a) was obtained.According to these derivatives and their IR, 1H and 13C NMR spectra, the by-product is 1,2,3,6-tetrahydro-4-phenyl-3-pyridine-methanol (4a).
