95838-58-7

Upstream product

• 149312-00-5 1ξ-(2-chloro-phenyl)-2-nitro-propene 
• 21731-17-9 methyl 3-aminocrotonate 
• 95838-90-7 5-<(Acetyl)(methoxycarbonyl)methylenamino>-4-(2-chlorphenyl)-4,5-dihydro-2,5-dimethyl-3-furancarbonsaeure-methylester 
• 105-45-3 acetoacetic acid methyl ester 

Relevant academic research and scientific papers

Synthesis of tetrasubstituted NH pyrroles and polysubstituted furans via an addition and cyclization strategy

The FeCl3-catalyzed addition and cyclization of enamino esters with nitroolefins provides a straightforward and general method for the synthesis of tetrasubstituted NH pyrroles. This novel method tolerates a wide range of functionality, and allows for rapid elaboration of the nitroolefins into a variety of substituted pyrroles in good yields. Further, an efficient KOAc-promoted addition and cyclization protocol toward substituted furans has been described as well. Georg Thieme Verlag Stuttgart · New York.

Heterocycles from α-Nitroolefins, VIII. - 2-Methyl-3-pyrrolecarboxylates from α-Nitroolefins and Acetoacetates

3-Pyrrolecarboxylates 4 can be prepared from α-nitroolefins 1 and acetoacetates 2 by two methods: (a) 1 and 2 react to give 4,5-dihydro-5-methyleneamino-3-furancarboxylates 3 which are hydrolyzed, (b) the nitronic acids 8, adducts of 1 and 2, yield with different reduction agents the heterocycles 4.