958457-35-7

Upstream product

• 958457-33-5 6-Hydroxymethyl-2-methyl-3-trifluoromethanesulfonyloxy-pyran-4(1H)-one 
• 958457-42-6 (4-{[3-(trifluoromethyl)phenyl]oxy}phenyl)boronic acid 
• 109272-29-9 meta-(4-bromophenoxy)-benzotrifluoride 
• 401-81-0 m-trifluoromethylphenyl iodide 
• 106-41-2 4-bromo-phenol 
• 2029-49-4 2,6-dihydroxymethyl-3-hydroxy-4-pyrone 
• 1506-67-8 3-hydroxy-6-hydroxymethyl-2-methyl-pyran-4-one 
• 501-30-4 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one 

Downstream Products

• 958457-37-9 6-(hydroxymethyl)-2-methyl-3-(4-{[3(trifluoromethy)phenyl]oxy}phenyl)-pyridin-4(1H)-one 

Relevant academic research and scientific papers

Potent antimalarial 4-pyridones with improved physico-chemical properties

Antimalarial 4-pyridones are a novel class of inhibitors of the plasmodial mitochondrial electron transport chain targeting Cytochrome bc1 (complex III). In general, the most potent 4-pyridones are lipophilic molecules with poor solubility in aqueous medi

Novel heterocyclic compounds

4-pyridone derivatives of Formula I and pharmaceutically acceptable derivatives thereof, processes for their preparation, pharmaceutical formulations thereof and their use in chemotherapy of certain parasitic infections such as malaria, are provided.