95853-92-2 Usage
Uses
Used in Pharmaceutical Industry:
1H-Indole-3-hexanoic acid, 5-chloro-1-methyl-2-(3-pyridinyl)is used as a thromboxane (TxA2) synthetase inhibitor for its high selectivity and potency in inhibiting the enzyme. This makes it a potential candidate for the development of drugs targeting various cardiovascular and inflammatory conditions.
Used in Cardiovascular Applications:
As a thromboxane (TxA2) synthetase inhibitor, 1H-Indole-3-hexanoic acid, 5-chloro-1-methyl-2-(3-pyridinyl)can be used to treat conditions such as thrombosis, atherosclerosis, and other cardiovascular diseases. By inhibiting the production of thromboxane A2, a potent vasoconstrictor and platelet aggregator, 1H-Indole-3-hexanoic acid, 5-chloro-1-methyl-2-(3-pyridinyl)- can help prevent blood clot formation and improve blood flow.
Used in Inflammatory Applications:
Due to its ability to inhibit thromboxane (TxA2) synthetase, 1H-Indole-3-hexanoic acid, 5-chloro-1-methyl-2-(3-pyridinyl)can also be used to treat various inflammatory conditions. By reducing the levels of thromboxane A2, which is involved in the inflammatory process, 1H-Indole-3-hexanoic acid, 5-chloro-1-methyl-2-(3-pyridinyl)- can help alleviate inflammation and associated symptoms.
Used in Drug Development:
1H-Indole-3-hexanoic acid, 5-chloro-1-methyl-2-(3-pyridinyl)can be used as a starting point for the development of new drugs targeting thromboxane (TxA2) synthetase. Its high selectivity and potency make it an attractive candidate for further research and optimization to create more effective and safer medications for various diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 95853-92-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,5,8,5 and 3 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 95853-92:
(7*9)+(6*5)+(5*8)+(4*5)+(3*3)+(2*9)+(1*2)=182
182 % 10 = 2
So 95853-92-2 is a valid CAS Registry Number.
95853-92-2Relevant academic research and scientific papers
3-Substituted-2-(heteroaryl) indoles
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, (2008/06/13)
Disclosed as thromboxane synthetase inhibitors are the compounds of formula STR1 wherein R1 represents hydrogen or lower alkyl; Ar represents 3-pyridyl or 1-imidazolyl, each unsubstituted or substituted by lower alkyl, carboxy, lower alkoxycarbonyl or carbamoyl; R2 and R3 independently represent hydrogen, lower alkyl, halogen, trifluoromethyl, hydroxy, lower alkoxy, carboxy lower alkyl, lower alkoxycarbonyl lower alkyl, carboxy, lower alkoxycarbonyl, or lower alkyl-(thio, sulfinyl or sulfonyl), or R2 and R3 together on adjacent carbon atoms represent lower alkylenedioxy; A represents straight chain or branched alkylene of 3 to 12 carbon atoms in which the number of the carbon atoms separating the indole nucleus from group B is 3 to 12, straight chain or branched alkenylene of 2 to 12 carbon atoms, straight chain or branched alkynylene of 2 to 12 carbon atoms, lower alkylenephenylene-lower (alkylene or alkenylene), lower alkylenephenylene, lower alkylene-(thio or oxy)-lower alkylene, lower alkylene-(thio or oxy)-phenylene, or lower alkylene-phenylene-(thio or oxy)-lower alkylene; B represents carboxy, esterified carboxy, carbamoyl, mono- or di-lower alkylcarbamoyl, hydroxymethyl, cyano, hydroxycarbamoyl, 5-tetrazolyl or formyl; the imidazolyl and pyridyl N-oxide thereof; or a pharmaceutically acceptable salt thereof; as well as their synthesis, pharmaceutical compositions thereof, and methods of treatment utilizing such compounds.
