95855-36-0Relevant academic research and scientific papers
Conjugate Hydrocyanation of Chalcone Derivatives Using Ethyl Cyanoacetate as an Organic Cyanide Source
Li, Zheng,Yin, Junjun
, p. 1179 - 1184 (2017/07/24)
The conjugate hydrocyanation of chalcone derivatives using ethyl cyanoacetate as an organic cyanide source at room temperature under open air and transition metal-free conditions was described. The protocol has advantages of using relatively cheap, less toxic, stable and easy-to-handle cyanating reagent, high yield, and mild reaction condition.
Thiourea-functionalized magnetic hydroxyapatite as a recyclable inorganic-organic hybrid nanocatalyst for conjugate hydrocyanation of chalcones with TMSCN
Oskouie, Afsaneh Arefi,Taheri, Salman,Mamani, Leila,Heydari, Akbar
, p. 6 - 10 (2015/09/21)
The recoverable nanomagnetic catalyst was manufactured based on thiourea modified magnetic hydroxyapatite. Magnetic hydroxyapatite (mHAp) as the inorganic-organic hybrid support was fabricated using co-precipitate condition and then modified via the covalently anchoring of 1-(3,5-bis(trifluoromethyl)phenyl-3-propyl)thiourea. The hybrid nano-catalyst has been identified by TEM, SEM, FTIR, BET, TGA, and XRD. This nanocatalyst appeared efficient and robust in the 1,4-addition reaction of TMSCN to α,β-unsaturated aromatic enones in excellent yields (85-96%) under mild reaction condition and simple work-up process. This recoverable organocatalyst has a great potential as an industrially viable and eco-safe catalyst.
Conjugate hydrocyanation of aromatic enones using potassium hexacyanoferrate(II) as an eco-friendly cyanide source
Li, Zheng,Liu, Chenhui,Zhang, Yupeng,Li, Rongzhi,Ma, Ben,Yang, Jingya
supporting information, p. 2567 - 2571 (2012/11/13)
A selective conjugate hydrocyanation of aromatic enones by a one-pot, two-step procedure using potassium hexacyanoferrate(II) as an original eco-friendly cyanide source, potassium hydroxide as a base, and benzoyl chloride as a promoter was described. This protocol has the advantages of a nontoxic cyanide source, high yield, and simple workup procedure. Georg Thieme Verlag Stuttgart · New York.
Synthesis of Heterocyclic Compounds, XXXVIII. - Five-membered Heterocycles by Cyclization of 3-Benzoyl-4-oxobutanenitriles
Ciller, J. A.,Seoane, C.,Soto, J.L.
, p. 51 - 57 (2007/10/02)
A synthesis of N-benzylidene-2-furanamines 8 by means of cyanide addition to acylchalcones 2, followed by piperidine-catalyzed cyclization in the presence of an aldehyde is reported.The 2-pyrrolones 4 are formed together with the compounds 8.In the absence of an aldehyde no furan is obtained.The intermediate 2-aryl-3-benzoyl-4-oxo-4-phenylbutanenitriles 3are easily isolated.The N-benzylidene-2-furanamines 9 are obtained from the oxonitriles 5.
