95859-63-5

Upstream product

• 95859-53-3 6-fluoro-8-nitrospiro-2',4'-dione 
• 95859-48-6 6-fluorospiro-2',4'-dione 
• 95859-52-2 6-fluoro-2'-iminospiro-4'-one hydrochloride 
• 114623-80-2 4-(ethoxycarbonyl)-6-fluoro-4-chromanol 
• 114623-81-3 4-chloro-4-(ethoxycarbonyl)-6-fluoro-chroman 
• 74187-57-8 6-fluoro-2,3-dihydro-4-cyano-4-[(trimethylsilyl)oxy]-4H-benzopyran 
• 74187-64-7 4-(ethoxycarbonimidoyl)-6-fluoro-4-chromanol 
• 66892-34-0 6-fluoro-4-chromanone 
• 98-88-4 benzoyl chloride 
• 95859-54-4 8-amino-6-fluorospiro-2',4'-dione 

Relevant academic research and scientific papers

Substituted spiro-2',4'-diones as aldose reductase inhibitors

Aldose reductase (EC 1.1.1.21) is believed to be involved in the pathogenesis of diabetic complications.Inhibitors of this enzyme could be useful for the treatment of diabetic cataracts and neuropathies.A series of spiro-2',4'-d

Novel thiazolidine derivatives

The invention relates to with novel thiazolidine derivatives of the formula STR1 wherein X is methylene, oxygen or sulfur; R1 is halogen; R2 is hydrogen, nitro, cyano, OR3 or NHR3 ; or R1 and R2 both simultaneously are hydrogen or nitro; R3 is hydrogen, alkyl, acyl, --CO--OR4 or --CO--NHR4 ; and R4 is alkyl, unsubstituted or substituted aryl or aralkyl, and their salts with physiologically compatible cations. The compounds of formula I are useful in the treatment of metabolic disorders.