95859-94-2Relevant academic research and scientific papers
METHOD OF PRODUCING ALPHA2-ADRENERGIC RECEPTOR AGONIST ACTIVITY
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, (2008/06/13)
A method of producing α 2-adrenergic receptor agonist activity by contacting an α 2-adrenergic receptor with an effective amount of a compound of the formula: STR1 wherein R 1, R 2, R 3 and R. sub.4 are independently selected from hydrogen or loweralkyl o
Conformationally defined adrenergic agents. 1. Design and synthesis of novel α2 selective adrenergic agents: Electrostatic repulsion based conformational prototypes
DeBernardis,Kerkman,Winn,Bush,Arendsen,McClellan,Kyncl,Basha
, p. 1398 - 1404 (2007/10/02)
A previous report of the adrenergic selectivity of 2- and 6-fluoronorepinephrine prompted us to formulate a hypothesis that accounted for this selectivity on the basis of a conformational preference induced by electrostatic repulsion between the aromatic
