958651-63-3Relevant academic research and scientific papers
Sulfonylureido thiazoles as fructose-1,6-bisphosphatase inhibitors for the treatment of Type-2 diabetes
Kitas, Eric,Mohr, Peter,Kuhn, Bernd,Hebeisen, Paul,Wessel, Hans Peter,Haap, Wolfgang,Ruf, Armin,Benz, Joerg,Joseph, Catherine,Huber, Walter,Sanchez, Ruben Alvarez,Paehler, Axel,Benardeau, Agnes,Gubler, Marcel,Schott, Brigitte,Tozzo, Effie
supporting information; experimental part, p. 594 - 599 (2010/05/19)
Sulfonylureido thiazoles were identified from a HTS campaign and optimized through a combination of structure-activity studies, X-ray crystallography and molecular modeling to yield potent inhibitors of fructose-1,6-bisphosphatase. Compound 12 showed favo
New FBPase inhibitors for diabetes
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Page/Page column 19, (2008/06/13)
Compounds of formula as well as pharmaceutically acceptable salts and esters thereof, wherein R1 to R3 have the significance given in the application and which can be used in the form of pharmaceutical compositions.
