958752-74-4Relevant academic research and scientific papers
Development of a Potent and Selective HDAC8 Inhibitor
Ingham, Oscar J.,Paranal, Ronald M.,Smith, William B.,Escobar, Randolph A.,Yueh, Han,Snyder, Tracy,Porco, John A.,Bradner, James E.,Beeler, Aaron B.
, p. 929 - 932 (2016/10/22)
A novel, isoform-selective inhibitor of histone deacetylase 8 (HDAC8) has been discovered by the repurposing of a diverse compound collection. Medicinal chemistry optimization led to the identification of a highly potent (0.8 nM) and selective inhibitor of HDAC8.
SELECTIVE HISTONE DEACETYLASE 8 INHIBITORS
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Sheet 1, (2014/08/07)
Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the activity of histone deacetylase 8 (HDAC8). Also described herein are methods of using such HDAC8 inhibitors, alone and in combination with other co
