95885-90-8Relevant academic research and scientific papers
Synthesis of Unsymmetrical Tertiary Phosphine Oxides via Sequential Substitution Reaction of Phosphonic Acid Dithioesters with Grignard Reagents
Nishiyama, Yoshitake,Hazama, Yuki,Yoshida, Suguru,Hosoya, Takamitsu
, p. 3899 - 3902 (2017)
A facile synthetic method for unsymmetrical tertiary phosphine oxides is reported. Sequential treatment of phosphonodithioic acid S,S-di(p-tolyl) esters with two Grignard reagents enabled the stepwise introduction of different carbon substituents on the phosphorus atom. The chemical stability of dithioesters and monosubstituted thioesters has enhanced the utility of this method, rendering a wide range of organophosphorus compounds easily available.
Turning regioselectivity into stereoselectivity: Efficient dual resolution of P-stereogenic phosphine oxides through bifurcation of the reaction pathway of a common intermediate
Nikitin, Kirill,Rajendran, Kamalraj V.,Mueller-Bunz, Helge,Gilheany, Declan G.
supporting information, p. 1906 - 1909 (2014/03/21)
Synthetic routes that provide facile access to either enantiomeric form of a target compound are particularly valuable. The crystallization-free dual resolution of phosphine oxides that gives highly enantioenriched materials (up to 94 % ee) in excellent y
