20335-96-0

Usage

Uses

Used in Plastics Industry:
Phosphine oxide, butylphenylis used as a flame retardant for improving the fire resistance of plastics. Its incorporation into plastic materials helps to slow down the rate of combustion and reduce the risk of fire-related incidents.
Used in Polyurethane Foam Industry:
In the polyurethane foam industry, Phosphine oxide, butylphenylis used as a flame retardant to enhance the fire safety of foam products. It is particularly useful in applications where foams are used in close proximity to potential ignition sources, such as in furniture and bedding.
Used in Epoxy Resin Industry:
Phosphine oxide, butylphenylis also utilized as a flame retardant in epoxy resins. Its addition to epoxy formulations improves the fire resistance of the final product, making it suitable for use in applications that require high-performance flame retardant materials, such as in electrical insulation and coatings.
However, it is important to note that Phosphine oxide, butylphenylhas been associated with potential health concerns, including reproductive and developmental toxicity. Therefore, it is crucial to handle this chemical with caution and adhere to safety guidelines when using products that contain Phosphine oxide, butylphenyl-.

Upstream product

• 109-72-8 n-butyllithium 
• 644-97-3 Dichlorophenylphosphine 
• 1619925-49-3 (-)-adamantyl hydrogenphenylphosphinate 
• 1619925-49-3 (+)-adamantyl hydrogenphenylphosphinate 
• 31352-60-0 (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl phenylphosphinate 
• 172823-06-2 (S_p)-O-(+)-menthyl-H-phosphinate 
• 1638-86-4 diethyl phenylphosphonite 
• 143490-03-3 O-isopropyl phenylphosphinate 
• 13336-50-0 isopropyl phenylphosphinate 
• 172487-18-2 ethyl Phenylphosphinate 
• 90826-86-1 Tetra-n-butylammonium-phenylcyanphosphid 
• 2946-59-0 dicyano(phenyl)phosphine 
• 693-04-9 butyl magnesium bromide 
• 90826-92-9 C₁₁H₁₄NP 

Downstream Products

• 95885-92-0 N-[4-(Butyl-phenyl-phosphinoyl)-phenyl]-acetamide 
• 10251-55-5 butyl(phenyl)phosphine 
• 55794-15-5 (S_p)-butylmethylphenylphoshine oxide 
• 87219-93-0 (R)-butyl methylphenylphosphine oxide 

Relevant academic research and scientific papers

Stereo- And Regioselective cis-Hydrophosphorylation of 1,3-Enynes Enabled by the Visible-Light Irradiation of NiCl2(PPh3)2

Described herein is a stereo- and regioselective cis-hydrophosphorylation reaction of the internal alkyne of 1,3-enynes that accesses various 1,3-dienes in good isolated yields. The visible-light irradiation of NiCl2(PPh3)2 allows the generation of highly reactive nickel(II)-phosphorus species that subsequently migrate into the internal alkyne of the 1,3-enynes and protonate the resulting vinyl nickel species, leading to various phosphinoyl 1,3-butadienes under mild reaction conditions.

B(C6F5)3-catalyzed O-H insertion reactions of diazoalkanes with phosphinic acids

A highly efficient base-, metal-, and oxidant-free catalytic O-H insertion reaction of diazoalkanes and phosphinic acids in the presence of B(C6F5)3has been developed. This powerful methodology provides a green approach towards the synthesis of a broad spectrum of α-phosphoryloxy carbonyl compounds with good to excellent yields (up to 99% yield). The protocol features the advantages of operational simplicity, high atom economy, practicality, easy scalability and environmental friendliness.

The Trityl-Cation Mediated Phosphine Oxides Reduction

Reduction of phosphine oxides into the corresponding phosphines using PhSiH3 as a reducing agent and Ph3C+[B(C6F5)4]? as an initiator is described. The process is highly efficient, reducing a broad range of secondary and tertiary alkyl and arylphosphines, bearing various functional groups in generally good yields. The reaction is believed to proceed through the generation of a silyl cation, which reaction with the phosphine oxide provides a phosphonium salt, further reduced by the silane to afford the desired phosphine along with siloxanes. (Figure presented.).

Practical Synthesis of Phosphinic Amides/Phosphoramidates through Catalytic Oxidative Coupling of Amines and P(O)?H Compounds

Herein, we report a highly efficient ZnI2-triggered oxidative cross-coupling reaction of P(O)?H compounds and amines. This operationally simple protocol provides unprecedented generic access to phosphinic amides/phosphoramidate derivatives in good yields and short reaction time. Besides, the reaction proceeds under mild conditions, which avoids the use of hazardous reagents, and is applicable to scale-up syntheses as well as late-stage functionalization of drug molecules. The stereospecific coupling is also achieved from readily available optically enriched P(O)?H compounds.

Controllable phosphorylation of thioesters: Selective synthesis of aryl and benzyl phosphoryl compounds

The controllable phosphorylations of thioesters were developed. When the reaction was catalyzed by a palladium catalyst, aryl or alkenyl phosphoryl compounds were generated through decarbonylative coupling, while the benzyl phosphoryl compounds were produced through deoxygenative coupling when the reaction was carried out in the presence of only a base.

Desymmetrization of Phosphinic Acids via Pd-Catalyzed Asymmetric Allylic Alkylation: Rapid Access to P-Chiral Phosphinates

The synthesis of P-chiral compounds is challenging, especially since useful catalytic methods for preparing such molecules are scarce. Herein we disclose a desymmetrization that employs phosphinic acids as prochiral nucleophiles in a Pd-catalyzed asymmetr

Preparation of O-Protected Cyanohydrins by Aerobic Oxidation of α-Substituted Malononitriles in the Presence of Diarylphosphine Oxides

A mild, reagent-cyanide-free, and efficient synthesis of O-phosphinoyl-protected cyanohydrins from readily available α-substituted malononitriles was realized using diarylphosphine oxides in the presence of O2. Mechanistic studies indicated that in addition to the initial aerobic oxidation of the malononitrile derivative notable features of this process include the formation of a tetrahedral intermediate and a subsequent intramolecular rearrangement. The phosphinoyl-protecting group can be removed by alcoholysis or by reduction with DIBAL-H.

Enantioselective Cu-Catalyzed Arylation of Secondary Phosphine Oxides with Diaryliodonium Salts toward the Synthesis of P-Chiral Phosphines

Catalytic synthesis of nonracemic P-chiral phosphine derivatives remains a significant challenge. Here we report Cu-catalyzed enantioselective arylation of secondary phosphine oxides with diaryliodonium salts for the synthesis of tertiary phosphine oxides

H-adamantylphosphinates as universal precursors of P-stereogenic compounds

A new family of H-adamantylphosphinates as universal precursors of P-stereogenic ligands was obtained in one step from commercial chlorophosphines. Both enantiomers of these air- and moisture-stable intermediates can easily be separated by semipreparative chiral HPLC on a gram scale and individually undergo stereoselective transformations to afford each enantiomer of a set of P-stereogenic compounds such as secondary phosphine oxides and boron-protected monophosphines.

P-STEREOGENIC CHIRAL PRECURSOR OF CHIRAL LIGANDS AND USE THEREOF

The present invention concerns phosphinate universal P-stereogenic chiral precursors of formula (I) for chiral ligands, preparation processes thereof and their use for the preparation of optically pure or enriched chiral ligands. Claimed are formula (I) c